Heparin

Question 1

Endogenous heparin is produced by?

Answer 1

• Basophils
• Mast cells
• Liver
  *

Question 2

Exogenous heparin is derived from?

Answer 2

Bovine lung and pig GI mucosa

Question 3

Heparin inhibits ______ and ________ pathways

Answer 3

Intrinsic and common

Question 4

___________ is the naturally occuring anticoagulant circulating in plasma.

Answer 4

Antithrombin

Question 5

Heparin binds to AT and accelerates its anticoagulant ability by ______ fold

Answer 5

1000 fold

Question 6

The heparin AT complex neutralizes thrombin and and activated factors ___, ___, ____ and 12

Answer 6

9, 10, 11 and 12

Question 7

Heparin inhibits platelet function

Answer 7

True

Question 8

Failed heparinization should prompt consideration for ____________

Answer 8

Antithrombin deficiency

Question 9

Heparin is metabolized by?

Answer 9

Heparinase

Question 10

Unfractionated heparin ranges from ______–_____ daltons

Answer 10

3000 - 30, 000

Question 11

What are the 2 pathways of degradation of heparin

Answer 11

1. Degradation by macrophages
2. Renal excretion

Question 12

Does heparin cross the placenta?

Answer 12

No, its safe to use in pregnancy

Question 13

The standard cardiac surgery dose of heparin is?

Answer 13

300 -400 U/kg

Question 14

Therapeutic heparinization occurs at what aPTT

Answer 14

1.5-2.5 times the normal

normal= 25-35 seconds

Question 15

ACT is affected by?

Answer 15

1. Hypothermia
2. Thrombocytopenia
3. Deficiency of fibrinogen, factor 7 or factor 12

Question 16

__________ clears the heparin-protamine complex

Answer 16

Reticuloendothelial system

Question 17

Protaine dose is

Answer 17

1 mg / 100U of circulating heparin