Contemporary cell based coagulation cascade

Question 1

The contemporary cell based cascade consists of three phases which are?

Answer 1

1. Initiation
2. Amplification
3. Propagation

Question 2

Initiation phase

Answer 2

• TF/7a activate the common pathway
• Limited amount of thrombin is formed due to production of tissue factor inhibitor (TFPI)
• Amount of thrombin produced is inadequate to activate fibrin.

Question 3

Amplification

Answer 3

Small amount of thrombin produced amplifies cascade by activation plt 5 and 11 laying groundwork for large scale thrombin production.

Question 4

Propagation phase

Answer 4

Large amounts of thrombin is produced

Begins at the activation of factor 10 by factors 8 and 9 on the surface of plt

Produces a positive feedback mechanism resulting in enough thrombin to activate fibrin