Drugs that affect bleeding

Question 1

What are the 4 classifications of antiplatelet drugs?

Answer 1

1. ADP receptor inhibitors
2. GpIIb/IIIa Receptor antagonists
3. COX inhibitors (non-specific)
4. COX inhibitors

Question 2

What are the 4 classes of anticoagulants

Answer 2

1. Heparins
2. Thrombin inhibitors
3. Factor 10 inhibitors.
4. Vitamin K antagonists

Question 3

What are the 3 types of drugs that increase bleeding

Answer 3

1. Antiplatelet drugs
2. Anticoagulants
3. Fibrinolytics

Question 4

Fondaparinux is classified as?

Answer 4

Factor 10 inhibitor anticoagulant

Question 5

what are the 2 drugs classified as COX 2 inhibitors

Answer 5

Refocoxib

Celecoxib

Question 6

Hold these for 7 days before elective surgery

Answer 6

Plavix, Aspirin (not usually stopped)

Question 7

You need to stop this drug 14 days before surgery

Answer 7

Ticlopidine (ADP receptor antagonist)

Question 8

Warfarin should be stopped for _______ days before surgery

Answer 8

2-4 days

Question 9

These drugs do not need to be stopped before surgery

Answer 9

Cox 2 inhibitors: Refocoxib and celecoxib

Question 10

Unfractionated heparin should be stopped __________ days before surgery

Answer 10

6 hrs

Question 11

tPA should be stopped _______ hrs before procedure

Answer 11

1 hr

Question 12

Name 2 plasminogen activation inhibitors

Answer 12

1. Aminocaproic Acid
2. Tranexamic Acid

Question 13

This drug inhibits plasmin, Kallikrein, thrombin and protein c

Answer 13

Aprotinin

Question 14

This drug stimulates factor 8 and vWF release

Answer 14

DDAVP

Question 15

Antifibrinolytics inhibit the conversion of Plasminogen to plasmin. Name 2

Answer 15

1. TXA
2. Amicar

Question 16

Fibrinolytics act as plasminogen activators promoting clot breakdown. Name 4

Answer 16

1. tPA
2. Urokinase
3. Reteplase
4. Alteplase

Question 17

Name 2 thrombin inhibitors anticoagulants

Answer 17

1. Argatroban
2. Bivalirudin