W9 Heterocycles and amine bond formation methods in drug synthesis

Question 1

Properties of Heterocyclic compounds:
Examples?

Answer 1

Cyclic compounds that have one or more atoms different than C (N, O, or S)
Heterocyclic compounds
Aromatics (special type of unsaturated with conjugated double bonds - 4, 6,
or 10 pi electrons) and non-aromatics (do not have pi electrons or they are not
conjugated)
Non-carbon atoms are referred to as heteroatoms.
Saturated = containing single bonds or unsaturated = containing double or
triple carbon to carbon bonds.
Different ring sizes (five- or six-member ring)

e.g. Pyridine= Aromatic, Unsaturated
Piperidine= Non-aromatic, Saturated

Question 2

Heterocyclic compounds Nomenclature

Question 3

Type of heteroatom present