Mock Questions (ICT) Flashcards
Which ONE of the following particle sizing techniques measures the Stokes’ diameter?
A. Sieves
B. Microscopy
C. Andreasen pipette
D. Cascade impactor
E. Photo correlation spectroscopy
D
Which ONE of the following particle sizing techniques measures the hydrodynamic
diameter?
A) Sieves
B) Microscopy
C) Andreasen pipette
D) Cascade impactor
E) Photon correlation spectroscopy
Photon correlation spectroscopy
Which ONE of the following does NOT indicate the flowability of a powder sample?
A) Calculating the Hausner ratio
B) Calculating the Carr’s index
C) Measuring the angle of repose of a powder sample
D) Comparing between the bulk and tapped density of a powder sample
E) Observing the bulk volume of a powder sample
E
Which ONE of the following equipment is NOT used for wet granulation?
A. High-shear granulation
B. Fluid-bed granulation
C. Roller compaction
D. Extrusion-spheronization
E. Spray-drying granulation
=C
Which one of the following is a LESS LIKELY side effect of the thiazide-like
diuretic class of drugs?
a) Hyponatremia
b) Hypovolemia
c) Hypotension
d) Hyperkalaemia
e) Metabolic alkalosis
D
Identify the LEAST ACCURATE statement about antianginal drugs
A. Dihydropyridine derivative calcium-channel blockers (such as amlodipine) may be effective in patients with Prinz metal angina (intense coronary artery spasm).
B. Nicorandil activates the ATP-sensitive K+ channels to enhance K+ efflux and hyperpolarisation of vascular smooth muscle cells.
C. Ivabradine selectively blocks the hyperpolarization-activated, cyclic nucleotide- gated (HCN) channels present within the SA nodes and lowers the heart rate without affecting the contractility of the cardiac muscle.
D. Ranolazine is a class ID sodium channel inhibitor which blocks the late inward sodium currents occurring during phase 2 of ventricular action potentials
E. β-adrenergic antagonist class of drugs, like bisoprolol, are a first-line option for treating patients with Printz metal angina (intense vasospasm) and heart failure
E
Which type of arrhythmia is characterised by rapid heartbeats originating above the ventricles?
A) Ventricular tachycardia
B) Ventricular fibrillation
C) Atrial flutter
D) Sinus bradycardia
E) Paroxysmal supraventricular tachycardia
E
Which ONE of the following statements regarding lung scintigraphy is INCORRECT?
A) Scintigraphy is an imaging technique
B) Diagnosis of some lung conditions is possible using scintigraphy
C) An external X-ray source is required in scintigraphy
D) Scintigraphy can be used to visualise particle deposition in the lungs
E) Gamma cameras are usually required for scintigraphy
=C
Which of the following Drug Metabolising Enzymes extensively metabolise amlodipine into its inactive metabolites?
A. CYP450 3A4/5
B. CYP450 2C9
C. CYP450 2C8
D. CYP450 2C19
E. CYP450 1A2
A
Which of the following statements is NOT TRUE about Leukotriene Receptor Antagonists (LTRAs)? (SAR)
A. They contain at least one hydrogen bond acceptor
B. There will be more than one hydrophobic region
C. There will be one or more acidic groups
D. The molecular weight is always less than 500 g/mol
E. The lipophilic tetraene tail of LTD4 can be imitated by several, more stable,
aromatic rings
=D
Which ONE of the following possible mechanisms of drug deposition in the alveolar regions is likely to be most important for particles of aerodynamic diameter
< 0.5 μm?
A. Inertial impaction
B. Sedimentation
C. Charge reflection
D. Interception
E. Diffusion
A
Examine the list of drugs below. Which of these are beta-2 receptor agonist drugs? Please identify the MOST appropriate answers from the list (A-E) below.
- Salbutamol
- Ipratropium
- Salmeterol
- Tiotropium
- Terbutaline
A. Answers 1,3 and 5 are beta 2 receptor agonists
B. Answers 2 and 5 are beta 2 receptor agonists
C. Answers 2 and 4 are beta 2 receptor agonists
D. Answers 4 and 5 are beta-2 receptor agonists
E. Answers 2 and 3 are beta 2 receptor agonists
A
Cystic fibrosis is caused by a mutation in the CFTR gene. What is the normal functioning of the protein that the CFTR gene encodes?
A. Transports chloride ions to the extracellular space
B. Transports chloride ions to the intracellular space
C. Transports sodium ions to the extracellular space
D. Transports sodium ions to the intracellular space
E. Transports bicarbonate ions intracellularly
A
Most appropriate medicine:
A patient develops atrial fibrillation and a rate control strategy is to be pursued. You are asked to recommend a suitable medicine by the consultant. The patient is asthmatic and experienced an acute asthma attack when prescribed atenolol in error many years ago.
A amiodarone
B apixaban
C bisoprolol
D diltiazem
E edoxaban
F flecainide
G rivaroxaban
H warfarin
D
Most appropriate medicine:
A patient with atrial fibrillation requires medication to reduce the risk of thromboembolic stroke. Among other things, you counsel them that this medicine should be taken once daily at the same time of day with food if a dose is missed it should be taken within 12 hours if remembered but omitted if not and that there is no easily-available antidote to treat bleeds.
A amiodarone
B apixaban
C bisoprolol
D diltiazem
E edoxaban
F flecainide
G rivaroxaban
H warfarin
G
Most appropriate medicine:
A patient with atrial fibrillation requires medication to reduce the risk of thromboembolic stroke. Among other things, you counsel them that this medicine interacts with lots of other medicines and that care should be taken with alcohol and certain foods. The international normalised ratio (INR) will need to be regularly monitored
A amiodarone
B apixaban
C bisoprolol
D diltiazem
E edoxaban
F flecainide
G rivaroxaban
H warfarin
=H
Most suitable medicine:
Heart failure is a common complication in patients who have had a myocardial infarction. It is an incurable condition, however, the use of medication can help slow the condition’s progression and improve a patient’s quality of life. You are working as a pharmacist in a
hospital heart failure clinic where you are reviewing patients’ medication.
Mrs B, a 65-year-old woman, has recently been diagnosed with heart failure with a preserved ejection fraction. She is complaining of feeling breathless and has swollen ankles.
A. Perindopril 2.5 mg tablets
B. Atenolol 50 mg tablets
C. Losartan 12.5 mg tablets
D. Furosemide 20 mg tablets
E. Metoprolol 100 mg tablets
F. Enalapril 2.5 mg tablets
G. Amlodipine 10 mg tablets
H. Spironolactone 25 mg tablets
=D
Most suitable medicine:
Heart failure is a common complication in patients who have had a myocardial infarction. It is an incurable condition, however, the use of medication can help slow the condition’s progression and improve a patient’s quality of life. You are working as a pharmacist in a
hospital heart failure clinic where you are reviewing patients’ medication.
Mr A, a 56-year-old man, has been newly diagnosed with heart failure with a reduced ejection fraction following a myocardial infarction. The patient is returning to your clinic because they cannot tolerate the ramipril that was previously started as they have developed a persistent cough, so they would like to try an alternative medication
A. Perindopril 2.5 mg tablets
B. Atenolol 50 mg tablets
C. Losartan 12.5 mg tablets
D. Furosemide 20 mg tablets
E. Metoprolol 100 mg tablets
F. Enalapril 2.5 mg tablets
G. Amlodipine 10 mg tablets
H. Spironolactone 25 mg tablets
=C
Acute coronary syndrome management
Mr P is a 64-year-old man with a medical history of stable angina. He requires medication to be used when required when playing golf, which is an activity that is known to bring on the patient’s angina pain
Most suitable medicine?
A. Fondaparinux 2.5 mg s/c
B. Clopidogrel 75 mg tablets
C. Bisoprolol 2.5 mg tablets
D. Ramipril 5 mg tablets
E. GTN 400 microgram spray
F. Paracetamol 500 mg tablets
G. Diltiazem 60 mg tablets
H. Atorvastatin 80 mg tablets
=E
Acute coronary syndrome management
Ms C is an 83-year-old woman who has been rushed to A&E with a suspected ST-elevated
myocardial infarction (STEMI) and requires medication. She received a 300 mg STAT dose of aspirin by the paramedics on her way to the hospital.
Most suitable medicine?
A. Fondaparinux 2.5 mg s/c
B. Clopidogrel 75 mg tablets
C. Bisoprolol 2.5 mg tablets
D. Ramipril 5 mg tablets
E. GTN 400 microgram spray
F. Paracetamol 500 mg tablets
G. Diltiazem 60 mg tablets
H. Atorvastatin 80 mg tablets
=A (anticoagulant) to improve survival post MI, also used to treat
High-risk drugs
Mr T, a 44-year-old man, has visited his GP pharmacist to review his treatment for chronic obstructive pulmonary disease (COPD). Over the last year, he had one moderate exacerbation,
not leading to hospital admission, and had an mMRC score of 3 and CAT score of 20. He is currently on an ipratropium inhaler. The pharmacist decides to stop ipratropium and starts him on a new drug.
Most suitable medicine:
A. Theophylline (oral)
B. Salbutamol (inhaled)
C. Montelukast (oral)
D. Beclometasone and vilanterol (inhaled)
E. Tiotropium (inhaled)
F. Prednisolone (oral)
G. Beclometasone (inhaled)
H. Budesonide (inhaled)
Ipratropium (SAMA)
= E (LAMA) brochodilator and anticholinergic
High-risk drugs:
Mr R, a 27-year-old man, has decided to stop smoking to improve his asthma treatment outcomes. He started severe vomiting, agitation, restlessness, dilated pupils, tachycardia,
hyperglycaemia, and convulsions and was admitted to A&E. The doctors interpretated that
these were toxicity symptoms related to his current drug treatment.
Most suitable medicine cause:
A. Theophylline (oral)
B. Salbutamol (inhaled)
C. Montelukast (oral)
D. Beclometasone and vilanterol (inhaled)
E. Tiotropium (inhaled)
F. Prednisolone (oral)
G. Beclometasone (inhaled)
H. Budesonide (inhaled)
=A (Xanthine) works by relaxing muscles around airways so they open up and you can breathe more easily -bronchodilator
Onset of toxicity can be delayed if a modified-release preparation is involved.
Legal timeframes:
For the scenario described, select the single most relevant timeframe from the list below. Each option may be used once, more than once, or not at all
A patient presents with a prescription for erectile dysfunction.A private prescription may state the number of times a medication may be repeated. The first dispensing must take place within a certain amount of time from of the date on the prescription.
A. 3 days B. 5 days C. 7 days D. 28 days E. 30 days F. 6 months G. 2 years H. 5 years
F
Legal timeframes:
For the scenario described, select the single most relevant timeframe from the list below. Each option may be used once, more than once, or not at all
Following dispensing of a private prescription, a record must be made in the POM register. The register should be retained for a certain amount of time from the date of the last entry in the register.
A. 3 days B. 5 days C. 7 days D. 28 days E. 30 days F. 6 months G. 2 years H. 5 years
G
Legal Requirements of Medicine Supply:
Private Rx
Mr R Abdul
41 Victoria Place
Swansea
Sildenafil tablets 50mg
Send 4
A Hargreves (sig)
Dr Aled Hargreves
GMC: 535332
Greenfields Surgery
Swansea
What else is required?
A. Date
B. Name
C. Quantity
D. Formulation
E. Strength
F. Patient name and address
G. Purpose for which it was sold or supplied
H. Signature of prescriber
=A
