W6 L1 Thu human population genetic 1

Question 1

What is human genetic

Answer 1

-the study of inheritance as it occurs in human being
-lead to the idea of eugenic, mating of individual w/ desirable trait to produce offspring w/ desirable trait, big issue
-eugenics idea spread around the world
=population genetic try to move away from eugenic idea

Question 2

Problem in human genetic today

Answer 2

-lack of diversity due to previous data taken from mainly Europeans population
-there are increase in global GWAS sources but still lacking compare to european

Question 3

How many ancestor does one have

Answer 3

• 2 parent
• 4 grand parent
  -8 great great parent
• ancestor at a generation= 2^n, but there will be a common ancestor eventually as human are not infinite

Question 4

Who does your genome come from

Answer 4

• 50% inherited from parent
• 25% from grand parent
  -great contribute 12.5%
  -great great contribute 6.25%
  percentage = 1/2 ^n
• a large proportion of our ancestor does not contribute to our genetic material

Question 5

How to talk about population genetic

Answer 5

• we need a formal means of describing processes in order to synthetize this observation into coherent, cohesive knowledge
• the formal mean: relatedness, heterozygosity, diversity, migration, population structure, mating choice, mutations, adaptation, evolution, etc

Question 6

Ways of thinking about a population

Answer 6

• full genealogy to trace back ancestor, remove those that did not contribute to next gen to find a common ancestor
  -make a coalescent tree

Question 7

what can coalescent let us do

Answer 7

-date relatedness and divergence between sequences
- coalescent modelling can be expanded to incorporate selection, expansion etc giving us a framework agaisnt which to test prediction and observation