W4 D2 - Pancreatitis

Question 1

Where is the pancreas located?

Answer 1

On the left side partially under the liver shaped like a fish

Question 2

Describe the location of the pancreatic head, tail, main pancreatic duct, sphincter of Oddi, common bile duct

Answer 2

head
* thicker end at midline by the duodenum

tail
* narrow tip on the left side

main pancreatic duct
* keeps digestive juices between pancreas and duodenum

sphincter of Oddi
* A muscle that opens and closes to allow bile / pancreatice juices into the small intestine

common bile duct
* carries bile from liver to gallbladder

Question 3

Describe the size and function of acini cells, islets of langerhans, beta cells, alpha cells

Answer 3

acini cells
* large cells on the outside
* releasing enzymes to aid in digestion

islets of langerhans
* small cells inside
* endocrine portion of pancreas

beta cells
* small cells inside
* insulin and blood sugar shifting into the cells

alpha cells
* small cells inside
* dump glucogon into the capillary

Question 4

What are the functions of the pancreas?

Answer 4

Exocrine - to outside of the body
* sodium bicarbonate maintains pH
* pancreatic enzymes

Endocrine - inside the body / into the blood
* insulin
* glucagon

Question 5

How does the pancreas aid in glucose control?

Question 6

What is pancreatitis?

Answer 6

An autodigestion issue where the pancreas ‘eats’ itself

Question 7

What are the different types of pancreatitis?

Answer 7

Mild acute
* no organ failure
* resolves quickly

Moderate acute
* brief organ failure
* resolves in 48 hours

Severe acute
* persistent organ failure
* ICU admission

Chronic
* long term
* alcohol consumption or unknown

Question 8

What is the pathophysiology and phases of pancreatitis?

Answer 8

Phase 1: early activiation of trypsinogen
* to trypsin
* begins to digest protein structures
* other enzymes become active

Phase 2: intra-pancreatic damage
* enzymes breakdown blood vessels / fat into fatty acids
* inflammatory mediators released

Phase 3: extra-pancreatic damage
* systemic affect from extensive damage
* digestive enzyme and inflammatory mediators spread to other organs

Question 9

What are management goals for pancreatitis?

Answer 9

1. identify and reverse cause
2. stabilize and support care
3. treat complications

Question 10

What are some causes of pancreatitis?

Answer 10

I GET SMASHED
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D -

Question 11

Turners vs. Cullens sign