W11

Question 1

whar are the basic stages and principles of brain development?

Answer 1

• birth of nneurons
• neuonal migration, differentiation and formation of cerebral cortex
• formation of precise axonal pathways (axonal growth) and synaptic connections (synaptogenesis) = formation of brain circuits/networks
• myelination of neurons

Question 2

basic formation of CNS?

Answer 2

1. formation of neural plate as layer rises

then neurulation happens:
2. neural plate folds = neural tube
3. neural tube = CNS (brain and spinal cord)

Question 3

birth of neurons?

Answer 3

• neurons are born from progenitor cells
• progenitor celsls divide to form new neurons - prolification
• disruption of this can have problems eg SZ eg microcephaly

Question 4

neuronal migration and differentiation - cerebral cortex

Answer 4

cerebral cortex is created through and inside outside sequence, early generated neurons form layers and they are bypassed by later neurons which migrate in layers over the neuronal plate