Vulvar + Vaginal Cancer

Question 1

Vaginal pagets disease VS breast paget disease ?

Answer 1

Low risk of underlying invasive carcinoma vs Paget’s disease of the breast

Question 2

paget cell histo ?

Answer 2

clear cytoplasm +
skinny red keratinized area +
Paget cells: Intraepithelial adenocarcinoma in situ

Question 3

HPV - related vulvar carcinoma cause ?

Answer 3

HPV-16 + 18

Question 4

histo of vulvar carcinoma ?

Answer 4

Histology: Squamous cell carcinoma: Keratin pearls
intercellular bridge

Question 4

Non-HPV related vulvar carcinoma cause ?

Answer 4

long standing Lichen sclerosus

Question 5

histo of SB ?

Answer 5

Histology: Desmin(+) spindle shaped cells

Question 6

Clear “grape-like” segmented mass protruding from vagina

Answer 6

sarcoma botryoides

Question 7

Female <4 years old + grape like mass in vagina ?

Answer 7

sarcoma botryoides

Question 7

Diethylstilbestrol exposure in utero → Vaginal adenosis (persistence of glandular co

Answer 7

clear cell carcinoma

Question 8

Pathophysiology: A subtype of embryonal rhabdomyosarcoma

which one ?

Answer 8

sarcoma botryoides

Question 8

Presentation:
○ Very thin shiny vulvar tissue
○ Atrophic vaginal introitus
○ Dyspareunia

Answer 8

vulvar carcinoma

Question 9

presentation of Extramammary Paget’s Disease:

Answer 9

Pruritus, redness, crusting, +/- ulcers

Question 10

Vaginal adenosis (persistence of glandular columnar epithelium)

Answer 10

clear cell carcinoma

26.4.2025
7.31AM