Polycystic Ovarian Syndrome

Question 1

Main defect in PCOS ?

Answer 1

+ Adipose tissue

Question 2

+ Adipose tissue effect in PCOS ?

Answer 2

+ E
+ Insulin resistance
+ Insulin

Question 3

+ insulin effect in PCOS ?

Answer 3

obesity + acanthosis nigricans

Question 4

+ insulin in PCOS aftereffect which imbalance ?

Answer 4

• Sex Hormone binding globulin
• SHBG
  + E & T

Question 5

Which axis imbalance in PCOS ?

Answer 5

+ LH
disruption of LH/FSH ratio

Question 6

+ Androgens: result ?

Answer 6

Hirsutism + Acne

Question 7

lab Dx of PCOS ?

Answer 7

Labs: ↑↑ LH, -/↓ FSH, ↑ Estrogen, ↑ Testosterone

Question 8

Ultrasonography of PCOS ?

Answer 8

US: Enlarged ovaries with multiple cysts

Question 9

↑ Estrogen, ↓ Progesterone:Result ?

Answer 9

Amenorrhea/Oligomenorrhea, enlarged ovaries, and infertility

endometrial hyperplasia

Question 10

why + androgen production
/ from where ?

Answer 10

↑ Androgen production (ovarian theca interna cells)

Question 11

↓ Conversion of testosterone to DHT = which drug ?

Answer 11

Finasteride: Inhibition of 5-𝜶-reductase

Question 12

Blocks conversion of androstenedione to estrone

which drugs ?

Answer 12

letrozole

Question 13

Androgen receptor antagonist

drugs >

Answer 13

flutamide

Question 14

promotes ovulation drug ?

Answer 14

clomiphene

Question 15

Establish estrogen/progesterone balance

drugs ?

Answer 15

hormonal contraceptives

Question 16

weight loss + insulin resistance

Answer 16

metformin

Question 17

Steroid receptor antagonist → Androgen blocking effects
\

drug ?

Answer 17

spironolactone
26.4.2025

8.01AM