Uterine Path-Adenomyosis + Endometrial Hyperplasia + Asherman syndrome Flashcards
Hyperplasia endometrial basalis layer → Invasion of endometrial tissue into the uterine myometrium
adenomysosis
Soft “boggy”, uniformly enlarged “globular” uterus +/- tenderness
adenomyosis
management of adenomyosis ?
GnRH agonist - leuprolide
↑ Estrogen → Hyperplasia of endometrial glandular tissue
endometrial hyperplasia
Mx of endrometrial hyperplasia ?
Progesterone (progestin) supplementation
Uterine trauma → Destruction of endometrial basalis layer → Adhesions/Fibrosis → Failure of endometrial regenration = ?
asherman syndrome
Proliferation of glandular cells with atypical cells showing extensive loss of cell polarity
endometrial hyperplasia
Amenorrhea, infertility, abnormal uterine bleeding, pelvic pain, recurrent pregnancy loss
asherman syndrome
etiology of ashermann syndrome
Prior dilation and curettage or uterine surgery
Histo of adenomyosis ?
Soft “boggy”, uniformly enlarged “globular” uterus +/- tenderness
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26.4.2025
pathophysiology of endometriosis ?
Extrauterine endometrial tissue → Ovaries (most common), uterosacral ligaments, rectouterine pouch peritoneum
cause of endometriosis ?
○ Retrograde blood or lymphatic flow
○ Metaplastic change of multipotent cells
Peritoneum: Yellow-brown “Powder burn” lesions
■ Ovary (endometrioma): Blood filled “chocolate cysts
Dx ??
endometriosis
Retained uterine contents → Inflammation +/- infection of the endometrial lining
Postpartum Endometritis
Acute: Growth of group B Streptococcus
○ Chronic: Growth of N. gonorrhoeae or A. israeli + Evidence of plasma cells on endometrial
Dx of – ?
postpartum endometritis
presentation of postpartum endometritis ?
vaginal discharge, abdominal pain, uterine tenderness, foul smelling lochia
