Klinefelter's syndrome Flashcards
1
Q
Chromosomal pattern ?
A
47XXY
2
Q
Main pathogenesis of KS ?
A
1.Testicular dysgenesis
2.Leydig cell dysfunction
3
Q
Testicular dysgenesis fate ?
A
Seminiferous tubule fibrosis
- sertoli cell
- inhibin
+ FSH
4
Q
Leydig cell dysfunction fate ?
A
- lEYDIG cell
- testosterone
+ LH
5
Q
Lab Dx ?
A
+ FSH
+ LH
- T
+ estrogen
6
Q
Pituitary + FSH + LH = name ?
A
Hypergonadotropic Hypogonadism
7
Q
Presentation of KS ?
A
- Infertility - Azoospermia
- Gynecomastia
- Inc Height
Testicular atrophy
8
Q
why gynecomastia in KS ?
A
- T
+ Estrogen
9
Q
why Inc height in KS ?
A
SHOX gene present in X gene
as Excess X gene
excess Height
10
Q
Risk of KS ?
A
Testicualar + Breast Cancer + Mitral valve prolapse
11
Q
why LH + ??
A
As T -
LESS (-) feedback to pituitary gland
12
Q
why FSH + ??
A
As Inhibin
LESS (-) feedback to PG
13
Q
Picture presentation of KS ?
A
Breast developement
wide hips
small testicular size
narrow shoulders
poor beard growth
