Sexual differentiation

Question 1

Testes / ovary developed from where ?

Answer 1

primordial germ cells at gonadal ridge

Question 2

Male tube name ?

Answer 2

Wolffian / Mesonephric duct

Question 3

Female duct name ?

Answer 3

Mullerian
/ Paramesonephric

Question 4

Internal structures of male ?

Answer 4

SEED
seminal vesicle
Epididymis
Ejaculatory duct
Ductus deferens

Question 5

internal structures of female ?

Answer 5

UUO
Oviduct
Uterus
Upper vagina

Question 6

SRY gene where ?

Answer 6

Male - Y

Question 7

SRY gene function ?

Answer 7

Testis determining Factor - TDF – Testis

Question 8

Testis fate ?? ( 2 cell ? )

Answer 8

sertoli cell
leydig cell

Question 9

sertoli cell function ?

Answer 9

sperm produce
AMH produce ?

Question 10

AMH function by sertoli cell ?

Answer 10

Suppress female Mullerian / paramesonephric duct

Question 11

leydig cell function ?

Answer 11

Testosterone release

Question 12

Testosterone fate ?

Answer 12

T —— DHT

Question 13

DHT by which enzyme ?

Answer 13

5-alpha-reductase

Question 14

5-A-R inhibitor drugs name ?

Answer 14

fenesterol
used in BPH

Question 15

Testosterone promote which duct ?

Answer 15

Mesonepohric / wolffian

Question 16

ovary fate which 2 cell ?

Answer 16

Theca + granulosa

Question 17

theca cell which hormone ?

Answer 17

Androgen —– estrogen

Question 18

estrogen fate ?

Answer 18

female internal genitalia

Question 19

SRY gene abcense where ?

Answer 19

in female
Paramesonephric duct persist

Question 20

what if No sertoli cell ?

Answer 20

• no sperm
• no AMH
• Both male + female external genitalia

Question 21

what if No 5-A-R ?

Answer 21

• no DHT
• NO internal genitalia
• typical external genitalia

Question 22

external genitalia in male ?

Answer 22

penis
scrotum
prostate

Question 23

external genitalia in female ?

Answer 23

clitoris
labia
distal vagina

Question 24

female all structure mainly b y which hormoen ?

Answer 24

estrogen

Question 25

genital tubercle -- to male ?

Answer 25

glans penis

Question 26

genital tubercle to female ?

Answer 26

glans clitoris

Question 27

urogenital sinus to male ? 2 gland

Answer 27

Prostate gland Bulbpurethral / cowper

Question 28

urogenital sinus to female ?

Answer 28

bartholin / vestibular glands urethral and paraurethral glands

Question 29

urogenital fold to male ?

Answer 29

ventral shaft of penis penile urethra

Question 30

urogenital fold to female ?

Answer 30

labia minora

Question 31

labioscrotal swelling to female ?

Answer 31

labia majora

Question 32

labioscrotal swelling to male >

Answer 32

scrotum 25.4.2025 9.18AM

Question 33

5 - A - r deficiency what happening ?

Answer 33

T +++ DHT ----- Ambiguouss genitalia

Question 34

Lab Dx of 5ARD ?

Answer 34

T:DHT >20 Karyotype XY normal estrogen

Question 34

why Bifid scrotum in 5ARD ?

Answer 34

labioscrotal sweeling

Question 34

why Phallus elongation in 5ARD ?

Answer 34

Genital tubercle

Question 35

why Hypospadias in 5ARD ?

Answer 35

urogenital fold

Question 36

What kind of genetic disease in 5ARD ?

Answer 36

Autosomal recessive

Question 36

Time limit of 5ARD ?

Answer 36

last untill puberty cause after that T will handle all

Question 37

Androgen insensitivity syndrome main features ?

Answer 37

Defect in androgen receptors - insensitive to androgen

Question 38

Lab of AIS ?

Answer 38

T cannot do its fucntion

Question 39

result of T not functioning in AIS ?

Answer 39

NO Mesonephric ducts

Question 40

Ducts control in AIS ??

Answer 40

T ---- No mesonephric ducts S - --- AMH -- NO paramesonephric ducts

Question 41

why female presenting in AIS ?

Answer 41

NO effetc of T

Question 42

rudimentary Vagina why in AIS ?

Answer 42

as immature upper vagina

Question 43

primary ameonorrhea in AIS >

Answer 43

NO uterus

Question 44

why cryptorchidism ?

Answer 44

as Testis need T to descend from Retropritoneum to Scrotum no T no descend Abnormal site

Question 45

absence pubic hair in AIS ??

Answer 45

imbalance of T and Estrogen receptor cannot act to the androgens

Question 46

breast developement in AIS ?

Answer 46

Hormone imbalance

Question 47

Genetic type of disease name of AIS ?

Answer 47

X-linked recessive 25.4.2025 9.50AM

Question 48

What type of disease is placental aromatase deficiency ??

Answer 48

Autosomal recessive

Question 49

normally Theca -- Androgen --- Estrogen need which hormone ??

Answer 49

Aromatase

Question 50

if PAD what lab Dx ?

Answer 50

Astrogen +++++ Estrogen ----- Androgen ++=

Question 51

effect of Androgen ++ in fetus ?>

Answer 51

fetal masculization

Question 52

so baby of XX - supposed to have female genitalia but if she have male genitalia what to think ?

Answer 52

Placental aromatase deficiency

Question 53

estrogen ---- effetc >>?

Answer 53

breast developement ---- female fat -- skinny mom achne facial hair mens irregular voice deeping

Question 54

why primary amenorrhea in PAD ?

Answer 54

Lack of estrogen

Question 55

another case where we can find masculinization of fetus ?

Answer 55

congenital adrenal hyperplasia

Question 56

CAH what happening ?

Answer 56

21alpha hydroxylase deficiencies - aldosteroine + androgen = Masculinization - BP +k+

Question 57

failure of GnRH to migrate to hypothalamus is which syndrome ?

Answer 57

Kallman syndrome

Question 58

Which pathway is inhibited in KS ?

Answer 58

olfactory bulb tooooooooo Preoptic nucleus

Question 59

lab finding of KS ?

Answer 59

- GnRH - LDH -FSH -T -E

Question 60

why height - in male ?

Answer 60

as - T

Question 61

WHY sperm count - in KS ?

Answer 61

- T

Question 62

Why primary amenorrhea in KS ?

Answer 62

- E

Question 63

Why ANOSMIA in KS ?

Answer 63

nasal tract near Olfactory bulb no smell

Question 64

lack of smell is called ?

Answer 64

anosmia

Question 65

anosmia is find --- ?

Answer 65

Kallman syndrome