von Willebrand's Disease

Question 1

What is BMBT

Answer 1

Buccal Mucosal Bleeding Time

Question 2

Clinical signs of von Willebrand’s Disease

Answer 2

• Easy bruising
• Prolonged bleeding estrus
  -Prolonged bleeding from venipuncture

Question 3

What is the function of Von Willebrand’s factor (vWF)?

Answer 3

Promotes platelet clumping during primary hemostasis

Question 4

What should be performed on an animal prior to surgery if they are suspected of having von Willebrand’s Disease?

Answer 4

BMBT (Buccal Mucosal Bleeding Time)

Question 5

Diagnosis of von Willebrand’s Disease

Answer 5

-BMBT (greater than 4 minutes)
-Positive ELISA
-DNA confirmation of gene defect
-Low level of vWF in plasma

Question 6

Treatment of von Willebrand’s Disease

Answer 6

1. Manage bleeding episodes with plasma or cryoprecipitate
2. Desmopressin acetate can be used to control bleeding during surgery
   (lasts 2 hours and increases factor VIII)