VN - Neurodegenerative Disorders - Week 9 Flashcards

1
Q

Parkinsons disease is characterised by the loss of what kind of neurons in what part of the brain?

A

The loss of dopaminergic neurons in the substantia nigra

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2
Q

What is the typical age of onset for parkinsons disease?

A

> 50, but can be younger

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3
Q

What is the inclusion criteria for the diagnosis of probable parkinsons disease (4)?

A
Bradykinesia
At least one of
-muscular rigidity
-4 to 6Hz rest tremor
-postural instability
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4
Q

Define bradykinesia.

A

Slowness of initiation of voluntary movement with progressive reduction in speed and amplitude of repetitive actions

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5
Q

What may postural instability not be caused by for a diagnosis to be confirmed as probable parkinsons disease (4)?

A

Visual, vestibular, cerebellar, or proprioceptive dysfunction

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6
Q

List 8 supportive (prospective) criteria that must be met for a diagnosis to be confirmed as probable parkinsons disease. Note how many of these are required (the minimum).

A
Unilateral onset
Rest tremor present
Progressive disorder
Persistent asymmetry affecting side of onset most
Excellent response to levodopa
Severe levodopa-induced chorea
Levodopa response for +5 years
Clinical course of +10 years
At least three of these must be met
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7
Q

List 3 common presentations of parkinsons disease.

A

Tremor
Impaired volitional movement
Better-preserved reflexive movements

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8
Q

Is there a cure for parkinsons disease?

A

No

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9
Q

Can treatment reverse the continuing loss of DA neurons seen in parkinsons disease?

A

No

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10
Q

What is the first line treatment for parkinsons disease? What about second?

A

First - MAO-B inhibitor

Second - levodopa/carbidopa

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11
Q

Are reflexive saccades affected in parkinsons disease?

A

Nearly unaffected

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12
Q

Are volitional saccades affected in parkinsons disease? Explain.

A

Their ability to generate them is grossly abnormal

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13
Q

Compare initiation of saccades to the accuracy (gain) of volitional saccades with parkinsons disease.

A

Initiation is more deficient compared to accuracy

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14
Q

Is pursuit gain affected in parkinsons disease?

A

It may or may not be

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15
Q

Is the inhibition of unwanted reflexive saccades intact with parkinsons disease? Is this typical for a neurodegenerative disorder?

A

It is intact

This is unusual

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16
Q

Are remembered saccades accurate or inaccurate with parkinsons disease? Explain why.

A

As they are volitional, they are inaccurate

17
Q

All in all, summarise whether the effects of parkinsons disease on ocular motor control is significant or not.

A

Relatively modest effects on ocular motor control

18
Q

Describe progressive supranuclear palsy, including its clinical features (4).

A

A cause of parkinsonism but distinct from parkinsons disease itself
Features are parkinsonism, pseudobulbar signs, dementia, supranuclear vertical gaze palsy

19
Q

List 5 ocular signs of progressive supranuclear palsy and note the percentage of individuals who present with them.

A
Photophobia
Ocular burning/dryness
Blurred vision
Diplopia
No neurological complaints
20
Q

What do individuals who have progressive supranuclear palsy often complain of, aside from the ocular signs (3)?

A

Difficulty reading
Watching the ground shake while walking
Seeing food on a plate
-also spillage of food while eating

21
Q

What regions of the brain are involved in progressive supranuclear palsy (4)?

A

Components of the basal ganglia such as the

  • subophthalmic nucleus
  • globus pallidum
  • substantia nigra
  • dentate nucleus
22
Q

Damage to what structure may cause pursuit defects in progressive supranuclear palsy?

A

Pontine nuclei

23
Q

In the context of neuropathology of progressive supranuclear palsy, what are gaze palsies associated with? What structure does this have significant projections with?

A

Greater neuron loss in the substantia nigra pars reticulata

Significant projections to the superior colliculus

24
Q

Relating to eye movement dysfunction, what is the hallmark of progressive supranuclear palsy?

A

Vertical saccade failure

25
Q

Are antisaccades more or less frequent in progressive supranuclear palsy compared to parkinsons disease?

A

Antisaccade errors are more frequent

26
Q

What is huntington disease characterised by?

A

Uncontrollable choreoform movements

27
Q

What is the neuropathology of huntington disease?

A

Gross atrophy of the caudate nucleus and putamen

Marked neuronal loss in the deep layers of the cerebral cortex

28
Q

Is the substantia nigra affected in huntington disease?

A

Yes

29
Q

List three significant ocular motor aread of the brain that are affected in huntington disease.

A

Globus pallidus
Substantia nigra
Cerebellum

30
Q

Describe how the clinical presentations of apathy and disinhibited behaviour with alzheimers disease can be seen in an optometric setting.

A

Corresponding eye movement abnormalities can be seen

  • diminished curiosity
  • antisaccade errors
31
Q

Would you expect to see deficits in saccades for an alzheimers patient?

A

Yes

32
Q

What do studies suggest that making uncorrected errors correlates with what? What do these studies suggest is the failure?

A

Dementia severity

-suggested there is a failure of error-monitoring

33
Q

With neimann-pick type c disease, describe how saccades and slow eye movements are affected.

A

Saccades are affected before slow eye movements.