VN - Neurodegenerative Disorders - Week 9 Flashcards
Parkinsons disease is characterised by the loss of what kind of neurons in what part of the brain?
The loss of dopaminergic neurons in the substantia nigra
What is the typical age of onset for parkinsons disease?
> 50, but can be younger
What is the inclusion criteria for the diagnosis of probable parkinsons disease (4)?
Bradykinesia At least one of -muscular rigidity -4 to 6Hz rest tremor -postural instability
Define bradykinesia.
Slowness of initiation of voluntary movement with progressive reduction in speed and amplitude of repetitive actions
What may postural instability not be caused by for a diagnosis to be confirmed as probable parkinsons disease (4)?
Visual, vestibular, cerebellar, or proprioceptive dysfunction
List 8 supportive (prospective) criteria that must be met for a diagnosis to be confirmed as probable parkinsons disease. Note how many of these are required (the minimum).
Unilateral onset Rest tremor present Progressive disorder Persistent asymmetry affecting side of onset most Excellent response to levodopa Severe levodopa-induced chorea Levodopa response for +5 years Clinical course of +10 years At least three of these must be met
List 3 common presentations of parkinsons disease.
Tremor
Impaired volitional movement
Better-preserved reflexive movements
Is there a cure for parkinsons disease?
No
Can treatment reverse the continuing loss of DA neurons seen in parkinsons disease?
No
What is the first line treatment for parkinsons disease? What about second?
First - MAO-B inhibitor
Second - levodopa/carbidopa
Are reflexive saccades affected in parkinsons disease?
Nearly unaffected
Are volitional saccades affected in parkinsons disease? Explain.
Their ability to generate them is grossly abnormal
Compare initiation of saccades to the accuracy (gain) of volitional saccades with parkinsons disease.
Initiation is more deficient compared to accuracy
Is pursuit gain affected in parkinsons disease?
It may or may not be
Is the inhibition of unwanted reflexive saccades intact with parkinsons disease? Is this typical for a neurodegenerative disorder?
It is intact
This is unusual