DIS - Optic Nerve II - Week 10 Flashcards

1
Q

What is megalopapilla, what is the lamina support like, and compared to normal, what is the risk of glaucoma like?

A

Congenitally large optic disc that has weak lamina support

Greater risk of glaucoma by 10x

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What kind of notch is often seen in megalopapilla?

A

Horizontal notch in the neuroretinal rim

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How should megalopapilla papients be treated as? Explain what this means (3).

A

Treat them as glaucoma patients

  • visual fields
  • IOP
  • optic nerve head appearance photo
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How should individuals with tight scleral sheaths be treated as?

A

Ischaemia suspects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Are blood vessel trifurcations an anomaly or normal?

A

Anomaly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

List three general kinds of anomalous blood vessel patterns to look out for. Are they common or rare? Are they reliable in isolation? Explain.

A
Branching trifurcations
Unusual insertions
Unusual tortuosity
Commonly normal, unreadable signs in isolation
-flag for close evaluation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is situs inversus and what two things is it often associated with?

A

It is a blood vessel distortion where there is a nasal detour of the temporal retinal vessels as they emerge from the disc
Associated with tilted discs and astigmatism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are congenital arterial loops? How may it affect vision? What can rarely happen (2)?

A

Blood vessel that leaves and returns to the same place
May give transient vision loss
Rarely gives occlusions and vitreous haemorrhages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Can congenital venous shunts be acquired?

A

Yes in addition to congenital

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What occurs with congenital venous shunts and give an example of a shunt.

A

Blood takes an alternative path, often choroidal flow

-optociliary shunt, from the retina to the choroid at the optic nerve head

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How can acquired optociliary shunts occur? What can it be a possible re-establishment of?

A

Caused by chronic venous flow compromise (venous stasis) at the optic nerve head
Possibly formed by re-establishment of previously defunt/empty channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

List four common causes of acquired optociliary shunts.

A

ON drusen
Vein occlusion
Problems with blood vessels around the optic nerve head (papillophlebitis)
Problems with optic nerve head (chronic papillodema, glaucoma, papillitis, optic nerve sheath meningioma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What happens to VA with optic nerve sheath meningioma?

A

Progressive vision loss from 6/6 to hand movement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Is RAPD present with optic nerve sheath meningioma?

A

Yes, if its unilateral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What happens to colour perception with optic nerve sheath meningioma?

A

Red saturation - dimmer in the impaired eye

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

List four stages of optic nerve appearance with optic nerve sheath meningioma.

A

Early optic nerve head swelling
Late optic atrophy
Venous congestion
Optociliary shunts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Does longstanding amblyopia ever get worse?

A

No, never

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What should suspected loops and shunts be differentiated from?

A

anastamoses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

How can congenital be differentiated from acquired optic loop/shunts?

A

Congenital - expect no VA loss or optic atrophy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What should you suspect if you see an acquired optociliary shunt, vision loss, and optic atrophy?

A

Optic nerve sheath meningioma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Who should you refer to if you suspect optic nerve sheath meningioma?

A

Neuroophthalmologist, ocular oncologist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Is the growth of optic nerve sheath meningioma rapid or slow? How does its position affect the difficulty of treatment? Can it diffuse intracranially or is it confined to the orbital space?

A

Slow growth, but the location is critical as it impacts vision
-is difficult due to proximity to the optic nerve
Can also diffuse intracranially

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What three serial exams should be considered for a case of suspected optic nerve sheath meningioma?

A

Visual fields
Peripapillary RNFL with OCT
MRIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What are congenital macrovessels? What path do they take (3)?

A

Abnormal single vein

  • either enter or cross foveal avascular zone
  • or cross horizontal raphe
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What two things are congenital macrovessels rarely associated with?

A

Exudates and haemorrhages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What visual acuity do you expect with congenital macrovessels?

A

Normal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What is the cilioretinal artery derived from?

A

Short posterior ciliary artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

In what percentage of eyes would a cilioretinal artery be found? Describe where it is and what kind of appearance it has.

A

20%
It is found emerging from the middle of the optic disc and runs horizontally toward the macula (90%), and is thin
-has a hooked appearance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Is it a good thing to have a cilioretinal artery or does it present many problems? Explain.

A

Good to have

-it supplies the macula, good to have, especially in cases of CRAO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

How can a cilioretinal artery be distinguished from any other vessel with a similar appearance emerging from the middle of the optic nerve head?

A

It has a distinct hooked appearance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What should you do and look out for if you see a cilioretinal artery?

A

Mostly conservative management

-photodocument for baseline and monitor for changes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

What are pigmented peripapillary crescents? How are they different from scleral crescents? What makes deeper layer visible? What causes displaced pigment?

A

They are a pigmented crescent in the peripapillary region
Scleral crescents are not pigmented
Loss of overlying tissue makes deeper layers visible
Mobilisation of the RPE gives displaced pigment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

List 5 possible causes of peripapillary crescents. Describe the look for each.

A
Congenital - smooth pigment
Ageing - degeneration, moth eaten look
Myopia - tilted disc, stretching, ectasia
Glaucoma - loss of tissue
Trauma - pigment clumping
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

What is optic nerve staphyloma?

A

Weakness in the scleral development at the optic nerve

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What changes can be seen at the optic nerve head with optic nerve staphyloma?

A

Posterior outpouching, with near normal optic nerve at the bottom of the pouch

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Compare the appearance of optic nerve staphyloma to thinning/ectasia.

A

It looks similar, but the outpouching is not the same as thinning/ectasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Is there risk of retinal detachment with optic nerve staphyloma as with coloboma? Explain.

A

Yes, but maybe not to the same extent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

What changes can be seen surrounding the optic nerve in optic nerve staphyloma (2)?

A

Pigmentary and degenerative changes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Is vision affected in optic nerve staphyloma?

A

Yes, from 6/9.5 to hand movement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

What three visual impairments are common with optic nerve staphyloma?

A

Strabismus
Amblyopia
Myopic astigmatism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

What is the prevalence of tilted discs?

A

3.5%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

What can usually be seen with tilted disc syndrome at the ONH (aside from tilting)?

A

Usually some ON hypoplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

In what percentage of tilted disc syndrome cases is it bilateral?

A

80%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

What happens to the nerve fibre layer with tilted disc syndrome?

A

Downstream thinning of the nerve fibre layer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Does tilted disc syndrome typically have normal or anomalous blood vessel insertion patterns?

A

Anomalous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

List three possible reasons for visual field defects due to tilted disc syndrome?

A

Retinal ectasia
Optic nerve hypoplasia
Possible pituitary involvement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Why should visual fields always be assessed side-by-side?

A

For possible homonymity

48
Q

What is generally the management for tilted disc syndrome?

A

Mostly conservative

-photodocument

49
Q

What should be done with the following if tilted disc syndrome is present:
Refractive error
Retinal thinning
Unilateral vision loss

A

Refractive error - myopic astigmatism correction
Retinal thinning - yearly review for potential rhegmatogenous retinal detachment
Unilateral vision loss - consider amblyopia treatment

50
Q

What type of retinal detachment is tilted disc syndrome a risk factor for?

A

Rhegmatogenous retinal detachment

51
Q

What kind of visual field defect requires care in tilted disc syndrome? Explain what should be done.

A

Bilateral visual field defects

  • tilted discs may mimic bitemporal loss
  • best to refer
52
Q

Is optic nerve drusen related to retinal drusen?

A

Noi

53
Q

What is the cause of optic nerve drusen? Describe the pathophysiology (4).

A

Caused by slowing of axoplasmic flow
Flower flow > axonal swelling at the lamina > rupture and extrusion of intracellular substances
Mitochondrial calcifications follow to form drusen

54
Q

What is the mode of inheritence for genetic optic nerve drusen?

A

Autosomal dominant

55
Q

List two diseases that can cause optic nerve drusen.

A

Papilloedema

Retinitis pigmentosa

56
Q

Can optic nerve drusen be idiopathic or is the cause generally always known?

A

Can be idiopathic

57
Q

What appearance does the cup have with optic nerve drusen?

A

Congested looking, small cup

58
Q

What is the blood vessel pattern like with optic nerve drusen?

A

Anomalous

59
Q

Where does optic nerve drusen usually first appear?

A

On the nasal disc margin

60
Q

How does optic nerve drusen affect vision and visual fields?

A

Typically normal VA but VF losses can occur with age - arcuate losses

61
Q

List three common peripapillary changes common with optic nerve drusen.

A

Optociliary shunts
Deep choroidal haemorrhages
RPE disruptions

62
Q

Does buried optic nerve drusen tend to apepar in younger or older patients? What may it look like and what is this called?

A

Buried drusen in younger people
May look like papilloedema
-pseudopapillodema

63
Q

Is buried optic nerve drusen easier or harder to find with a normal view? What is the recommendation here?

A

Harder

-use autofluorescence, OCT, or ultrasound for subtle cases

64
Q

Compare how papilloedema and ON drusen appear on OCT.

A

Papilloedema - smooth elevation

Drusen - lumpy/bumpy

65
Q

Compare how the cup appears with papilloedema and ON drusen.

A

Papilloedema - absent

Drusen - present?

66
Q

Compare the presence of anomalous blood vessels in papilloedema and ON drusen.

A

Papilloedma - absent

Drusen - present?

67
Q

Compare how the RNFL appears with papilloedema and ON drusen.

A

Papilloedema - dirty, not visible

Drusen - clean, visible

68
Q

Compare the presence of spontaneous venous pulsation with papilloedema and ON drusen.

A

Papilloedema - absent (digital?)

Drusen - visible?

69
Q

in what percentage of ON drusen cases is spontaneous venous pulsation thought to be present?

A

~20%

70
Q

Compare the type of haemorrhages seen with papilloedema and ON drusen.

A

Papillodema - multiple flame

Drusen - deep choroidal

71
Q

Compare whether or not you would expect papilloedema and ON drusen to affect a patient’s relatives.

A

Papilloedema - normal relatives

Drusen - affected (according to autosomal dominant inheritence)

72
Q

Compare whether or not headaches (and other neurologic pathology) are present with papilloedema and ON drusen.

A

Papillodema - present

Drusen - absent

73
Q

How should patients with ON drusen be managed (2)? What about if there is a visual field defect (2)?

A

Differentiate between buried ON drusen and true papillodema
Monitor with age for ischaemic events
If visual field defect present, monitor for progression
-possibly more susceptible glaucomatous damage, consider IOP lowering treatment

74
Q

What kind of disorders are phakomatoses?

A

Neurocutaneous disorders

75
Q

What are phakomatoses characterised by?

A

Multiple tumours

76
Q

Are phakomatoses malignant or benign? Explain.

A

Are or can become malignant

77
Q

Why are phakomatoses of concern to optometrists?

A

Because all have ophthalmic tumours as the primary and is the most prominent clinical manifestationd in some affected individuals

78
Q

What are hamartomas? Are they benign or malignant? Do these cells all descend from one single mutated cell? Explain

A

Overgrowths of local tissue that do not invade or spread

-typically they are multiple aberrant cells, rather than having a single common aberrant cell

79
Q
Define the base tissue for the following hamartomas:
Haemangioma
Neuroma
Neurofibroma
Astrocytoma
Melanocytoma
Choristoma
A
Haemangioma - blood vessels
Neuroma - peripheral nerves
Neurofibroma - nerve sheaths
Astrocytoma - astrocytes
Melanocytoma - melanocytes
Choristoma - bone
80
Q

What percentage of hamartoma is associated with other neoplasia? What is the significance of this?

A

15-25%

-some of these can be malignant

81
Q

What is a racemose angioma? Is it congenital or acquired?

A

Twisty, corkscrew, frilly, tortuous vessels

-congenital

82
Q

If a racemose angioma is local/regional, what should be noted and why?

A

Find where they end

-could lead to a mass/tumour

83
Q

List two possible outcomes if a racemose angioma ruptures.

A

Intraocular haemorrhage

-death if haemorrhaging intracranially

84
Q

What can be said of retinal haemangiomas if they are in isolation?

A

Possibly benign

85
Q

What syndrome are retinal haemangiomas an indication for?

A

Von Hippel Lindau syndrome

86
Q

At what age does Von Hippel Lindau syndrome manifest?

A

20 to 35 yoa

87
Q

What three lesions may be seen with Von Hippel Lindau syndrome?

A

Retinal, spinal cord, and cerebellar lesions

88
Q

What are the blood vessels like with Von Hippel Lindau syndrome?

A

Tortuous

89
Q

Are exudates present with Von Hippel Lindau syndrome?

A

Yes

90
Q

What percent of Von Hippel Lindau syndrome cases are bilateral?

A

50%

91
Q

List two organs affected by Von Hippel Lindau syndrome other than the eye.

A

Pancreas

Liver

92
Q

List three cerebral complications of Von Hippel Lindau syndrome.

A

Epilepsy
Psychiatric disorders
Dementia

93
Q

What does sturge-weber syndrome affect the development of?

A

Blood vessels

94
Q

What is characteristic of sturge-weber syndrome?

A

Portwine stain

  • forehead
  • scalp
  • around the eye
95
Q

What can be seen in abundance near the skin surface of the port-wine stain in sturge-weber syndrome?

A

Capillaries

96
Q

What three tissues/areas of the bodies are involved with sturge-weber syndrome? Describe how.

A

Skin (port-wine stain)
choroid (choroidal haemangioma)
Central nervous system (siezures)

97
Q

Describe the association between sturge-weber syndrome and glaucoma. What can be determined by the position of the port-wine stain?

A

Open angle glaucoma in 30-70%

60% glaucoma ipsilateral to the port-wine stain

98
Q

What nerve do most cases of sturge-weber syndrome involve?

A

Ophthalmic division of the trigeminal nerve

99
Q

How likely is sturge-weber syndrome with non-ophthalmic division involvement to give glaucoma compared to ophthalmic involvement?

A

Less likely

100
Q

List four potential systemic complications of sturge-weber syndrome.

A

Cerebral angioma
Epilepsy
Hemiparesis
Retardation

101
Q

What can be said of choroidal haemangioma if it is isolated?

A

It is benign

102
Q

Can choroidal haemangioma be part of sturge-weber syndrome?

A

It might

103
Q

How does choroidal haemagiomas appear (colour and depth)?

A

Deep, orange/dark raised retinal region

104
Q

What is common on the retinal surface of choroidal haemiangiomas?

A

Glial proliferation

105
Q

What is common in the vitreous with choroidal haemangiomas?

A

White vitreal condensations

106
Q

How do choroidal haemangiomas affect visual fields?

A

Causes local VF loss

107
Q

List two risks associated with choroidal haemangiomas.

A

Retinal detachment

Glaucoma

108
Q

What disease can neurofibromatosis be seen in?

A

Von recklinhausens disease

109
Q

What five ocular involvements can be seen in von recklinhausens disease?

A
Lumps (neurofibroma) in lids
Iris (lisch nodule)
Optic nerve head
Retina
Skin
110
Q

What ocular condition can manifest with tuberous sclerosis?

A

Retinal astrocytoma

111
Q

List the three types of retinal astrocytoma.

A

Flat - smooth, semitransparent
Raised - calcified, multinodular
Intermediate

112
Q

Aside from the ocular manifestations, what is also commonly seen with tuberous sclerosis?

A

Angiofibromas (small red bumps on the face)

113
Q

What is a melanocytoma? What may it form with age?

A

Pigmentary tumour of the optic nerve

May form malignant melanoma with age

114
Q

What is a potential complication neurofibromas and what is it a risk factor for?

A

Ptosis due to the weight

Risk fo glaucoma

115
Q

What is the management for all these lesions (2)?

A

Watch for stability

VA and visual fields