Viuda negra Flashcards

1
Q

Orden, familia, genero

A

aranea, therideae, latrodertus matans

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2
Q

Principal funcion del veneno

A

Neurotoxinas, ataque a SNC

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3
Q

Principal toxina de veneno

A

alfa latrodetina

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4
Q

MA de latrodetina

A
  1. Actua en membrana citoplasmatica
  2. altera la permeabilidad de iones
  3. Canales de Ca a tarves de latrotofina
  4. iberacion de acetil colina y catecolaminas
  5. exocitosis de nueronas y celulas endocrinas
  6. secresion masiva de NT
  7. receptores de neurexina
    BLOQUEO DE TRANSMISON NERVIOSA
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5
Q

Resumen del mecanismo de acción

A
  • Liberación excesiva de ACh (se agota)
  • Paralisis
  • Producción de catecolaminas y bradicinina
  • Hipereactivdad autosomica
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6
Q

Fases de envenenamiento

A

I. Exacerbación (30min a 48h)
II. Disipación (48h a 72h)
III. Residual (semanas a meses)

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7
Q

Manifestaciones locales

A

Dolor intenso en mordedura
Parestesias locales
Piloerección

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8
Q

Manifestacione sitemicas

A

DOLOR ABDOMINAL
Diforesis
Mialgias
Parestesias
Priapismo
Hiperreflexia
Delirio
Silorrea
Retención urinaria
Trismus

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9
Q

Tratamiento

A

Aracmyn

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10
Q

Como se da el antidoto

A

IV disuelto en 20ml de Sol. salina 0.9% por 2 minutos

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