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TOXICOLOGIA > Toxicologia intro > Flashcards

Toxicologia intro Flashcards

1
Q

Diferencia entre toxicologia y toxinologia

A

Toxicologia: sindromes toxicos
Toxinologia: toxinas y venenos

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2
Q

Cuales son los sindromes toxicos

A

Anticolinergico
Colinergico
Opiode
Simpaticomimetico
Sedativo-Hipnotico

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3
Q

Colinergico: FC, FR, Tº, Pupilas, Sonidos intestinales, diaforesis

A

=FC, =FR, =Tº, miosis, incremetados (efecto en musculo liso), humedad en mucosas por aumento de secresión

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3
Q

Anticolinergico: FC, FR, Tº, Pupilas, Sonidos intestinales, diaforesis

A

↑FC, =FR, ↑Tº, Midriasis, inhibidos, sequedad de mucosas

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4
Q

Opiode: FC, FR, Tº, Pupilas, Sonidos intestinales, diaforesis

A

↓FC, ↓FR, ↓Tº, miosis extrema , inhibidos, sequedad de mucosas

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5
Q

Simpaticomimetico: FC, FR, Tº, Pupilas, Sonidos intestinales, diaforesis

A

↑FC, =FR, ↑Tº, miosis, aumentados, aumento de secresion

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6
Q

Sed/Hip (Bzd): FC, FR, Tº, Pupilas, Sonidos intestinales, diaforesis

A

↓FC, ↓FR, ↓Tº, no cambios pupilares , inhibidos, sequedad de mucosas

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7
Q

Farmacos potenicalemente toxicos

A

Digoxina
Benzos
Opiodes
Valproato
Antidepresivos
Carbamacepina
Teofilina
Salicilatos
Anticoagulantes
Insulinas
Paracetamol
Fenitoina
Litio
Lidocaina

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8
Q

Metodos de descontaminación

A

Vaciamiento gastrico
Carbón activado
Irrigación intestinal
Cx y endoscopia
Hemodialisis
Dialisis peritoneal
Plasmaferisis y exanguinotransfusión

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9
Q

tx opio

A

naloxona

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10
Q

tx benzos

A

flumazenil

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11
Q

tx paracetamol

A

n aceticisteina

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12
Q

tx insulinas

A

glucosa

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13
Q

tx betabloqueantes

A

glucagon

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14
Q

tx Organofosforados y carbamato (colinergicos)

A

atropina

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15
Q

tx anticolinergicos

A

fisostigmina

16
Q

tx metanol

A

etanol

17
Q

tx digitalicos

A

anticuerpos especificos

18
Q

tx heparina

A

protamina

19
Q

tx plomo, mercurio o arsenico

A

dimecarpol

20
Q

tx antidepresivos triciclicos

A

bicarbonato

21
Q

Ceriterios para eliminación de un tóxico por hemodíalisis

A

Lipo e hidrosolubilidad
Peso molecular
Union a proteinas
Volumen de distribución

22
Q

Indicaciones para lavado gastrico

A

Ingesta <2 horas
Sonda + alicuotas de 10ml/kg en niños y 250 ml en adultos

23
Q

Indicaciones grls de carbon activado

A

Farmaco que permanece en tracto
Dosis: 0.5 a 1 g/kg en una dilución de 4 ml de manitol al 20%

24
Q

Irrigación intestinal total

A

Xenobiótico con periodo de latencia para liberación y no se adhiere a CA
- Polietienglicol 3350
Dosis: 1.5 a 2 L/hora

25
Q

Criteros LADME en farmacocinetica

A

Liberación
Absorción
Distribución
Metabolismo
Eliminación

TOXICOLOGIA (7 decks)

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