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Viruses Flashcards

1
Q

Hep B family and features

A

Hepadnavirus

DNA virus that is envloped

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2
Q

Env gene products

A
  • gp120
  • gp41
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3
Q

CMV Dx:

A

Owl-eye inclusion in biopsy material and urine

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4
Q

Parvovirus major family of

A

B19

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5
Q

Treatment of suspected Rabies

A
  1. Postexposure prophylaxis
  2. One dose of human Rabies Ig
  3. Five dose of rabies vaccine (day 3, 7, 14, 28)
  4. Killed virus vaccine
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6
Q

Mumps symptoms and complications

A

Symptoms

Bilateral parotitis with fever, headache, and malasie

Complications

Pancreatitis, orchitis, and meningoencephalititis

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7
Q

Only DNA virus NOT ds

A

Parvo

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8
Q

HIV capsid protein

A

p24

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9
Q

Hep D family and features

A

No family

Circular RNA in envelope

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10
Q

Peak incidence of Picornaviridae

A

Summer/fall

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11
Q

HIV core nucleocapsid protein

A

p7p9

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12
Q

Major viruses of Pox family

A
  1. Variola
  2. Vaccinia
  3. Molluscum contagiosum
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13
Q

Kaposi sarcoma caused by

A

AIDs pts with HHV-8

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14
Q

EBV Target cell and receptor

A

B lymphocytes

CD21=CR2

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15
Q

Hep B disease presentation

A

Acute, occasionally severe

Chronic

Primary hepatocellular carcinoma, cirrhosis

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16
Q

Rabies is what family of viruses

A

Rhabdovirus

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17
Q

Hemagglutinin is

A

Surface glycoproteins that bind to sialic acid receptors

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18
Q

Negative sense RNA

A

Template strand

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19
Q

Reovirus transmission and disease

A
  1. Fecal-oral/respiratory
  2. Common cold, gastroenteritits
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20
Q

B19 pathogenesis

A

Infects erythroid progenitor cells resulting in cell lysis causing Anemia only significant to pts with Sickle cell

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21
Q

School-aged child to adult

Acute viral gastroenteritis (noninflammatory)

Cruise ship

A

Norwalk

Calicivirdae

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22
Q

Meningoencephalitis due to HSV

A

Fever, headache, confusion

Focal temporal lesion

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23
Q

Plantar warts due to HPV are what serotype

A

1

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24
Q

Rubella disease

A

German measles

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25
Q

Positive sense RNA

A

Coding strand

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26
Q

Congenital Rubella syndrome symptoms

A
  1. PDA
  2. Pulmonary stenosis
  3. Cataracts
  4. Microcephaly
  5. Deafness
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27
Q

ss(-)RNA viruses carry

A

RNA-dependent RNA polymerase

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28
Q

Hep A family and features

A

Picornavirus

RNA virus in Naked Capsid

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29
Q

Koplik spots are

A

Seen in measles

Maculopapular rash from the ears down => giant cell pneumonia

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30
Q

Coxsackie A diseases

A
  1. Hand, foot and mouth
  2. Herpangina
  3. Aseptic meningitis
  4. Acute lymphoglandular pharyngitis
  5. Common cold
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31
Q

German measles symptoms

A

Erythematous rash begins on face and progresses to torso

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32
Q
  1. Young adult with ARD
  2. Swimmers and shipyard workers with nonpurulent conjunctivitis
  3. Daycare: viral gastroenteritis
A

Adenovirus

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33
Q

Which DNA virus has virion-associated polymerase

A

Hepadnavirus

Poxvirus

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34
Q

Pain Results From Our Bunions Always

A

ss(-)RNA viruses

  1. Paramyxovirus
  2. Rhabdovirus
  3. Filovirus
  4. Orthomyxovirus
  5. Bunyavirus
  6. Arenavirus
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35
Q

Hep C family and featuers

A

Flavivirus

RNA virus in Envelope

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36
Q
  1. Young adults (wrestling, swim team)
  2. Umbilicated warts
  3. Eosinophilic cytoplasmic inclusion bodies
A

Molluscum contagiosum

Poxviridae

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37
Q

VZV latent in

A

Dorsal Root Ganglia

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38
Q

EBV malignancies

A
  1. Burkitt lymphoma (c-myc oncogene)
  2. Nasopharyngeal carcinoma (Asia)
  3. Hodgkin lymphoma
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39
Q
  1. Synchronous rash begins in mouth and spreads to face and body
  2. Guarnieri bodies (intracytoplasmic inclusions)
A

Variola/smallpox

Poxviridae

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40
Q

Roseola cuased by

A

HHV-6

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41
Q

Paramyxovirus viruses

A
  1. Mumps
  2. Measles
  3. RSV
  4. Parainfluenza
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42
Q

Rabies virus binds to

A

Nicotinic Acetylcholine receptors

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43
Q

What is used to DX HSV?

A

Tzank smear to show the formation of multinucleated giant cells and Cowdry type A intranuclear inclusion

44
Q

Flavivirus viruses

A
  1. Yellow fever
  2. Dengue
  3. St. Louis encephalitis
  4. Hep C
  5. West Nile Virus
45
Q

Call Henry Pico Flo To Come Rightaway

A

Positive Sense Viruses

  1. Calici virus
  2. Hepevirus
  3. Picorna
  4. Flavivirus
  5. Togovirus
  6. Corona virus
  7. Retro virus
46
Q

Only DNA virus not Icosahedral

A

Pox: brick-shaped

47
Q
  1. Heterophile-negative mononucleosis in children and adults
  2. Neonate with Jaundice, hepatosplenomegaly, thrombocytic purpura
  3. Owl-eye intranuclear inclusion bodies
48
Q

Ebola is what type of virus

49
Q

HIV target cell and receptor

A

Th cells, Macrophages, Microglia

CD4 plus CCR5 or CXCR4

50
Q

CMV latency in

A

Mononuclear cells

51
Q

Rhinovirus target cell and receptor

A

Resp epithelial cells

ICAM-1

52
Q

Fusion proteins action

A

destabilizes host membrane

53
Q

Phenotypic mixing

A

When related viruses coinfect cell then the resulting proteins on the surface are a mixture capsid of the two viruses

Internal NA remains the same

54
Q

Hepevirus viruses

55
Q

Most +ssRNA viruses intermediate Replicative form

56
Q

Downey cells

A

Atypical reactive T cells due to EBV latency in B cells

57
Q

Measles virus distinguishing characteristics

A

Hemagglutinin glycoprotein and fusion protein

No neuraminidase

58
Q

Rotavirus transmission and disease

A

Fecal-oral

Gastroenteritis with no blood or pus

59
Q

Only dsRNA virus

60
Q

CMV disease

A
  1. Cytomegalic inclusion disease
  2. Mononucleosis
  3. Interstitial pneumonitis
  4. CMV retinitis
61
Q

Hep E family and features

A

Hepevirus

RNA virus in Naked capsid

62
Q

+RNA virus mRNA transcribed from

63
Q

Antigenic drift

A
  1. Influenza A and B
  2. Slight changes in antigenicity due to mutation in H and/or N
  3. Causes epidemics
64
Q

B19 disease in fetus

A
  1. Sever anemia
  2. Congestive heart failure
  3. Hydrop fetalis
  4. Spontaneous abortion
65
Q

B19 disease in children/adults

A
  1. Fifth diesase causing Erythema infectiosum, slapped cheek fever
  2. Flu-like symptoms with facial rash
66
Q

Togovirus viruses

A
  1. Rubella
  2. WEE, EEE
  3. Venezuelan encephalitis
67
Q

Polyomaviridae viruses

A

BK (Renal disease in AIDs)

JC (PML in AIDs)

68
Q

HIV matrix protein

69
Q

HSV is latent in

A

Trigeminal ganglion

70
Q

Measles virus pathogenesis

A

Ability to cause cell:cell fusion leading to giant cells

Viruses can escape immune detection

71
Q

PEE Co Rn A Viruses

A

Picornaviruses

  • Polio
  • Entero
  • Echo
  • Coxsackie
  • Rhino
  • A Hep
72
Q

Which Hep is transmitted fecal-oral

A

Hep A and Hep E

73
Q

Pardon PaPa As He Has Pox

A

DNA virus

  1. Parvo virus (Naked)
  2. Papilloma (Naked)
  3. Polyoma (Naked)
  4. Adenovirus (Naked)
  5. Hepadna (Envoloped)
  6. Herpes (Envoloped)
  7. Pox (Envoloped)
74
Q

Neuraminidase is

A

clips off sialic acid thus aiding in release of virus

75
Q

Reoviridae viruses

A
  1. Reovirus
  2. Rotavirus
  3. Colorado Tick Fever Virus
76
Q

Rabies target cell and receptor

A

Neurons

Ach receptors

77
Q

Pharyngoconjunctivitis chx

A

Swimming pool conjunctivitis, pink eye

Fever, sore throat, coryza and red eye

NONPURULENT

78
Q

Calicivirus viruses

A

Norwalk

Noro-like virus

79
Q

Only DNA virus that doesn’t replicate in nucleus

80
Q
  1. Young adult with fever, lymphadenopathy, splenomegaly
  2. Downey type 2 atypical T lymphocytes
  3. Heterophile (monospot) postive
81
Q

Polio pathogenesis

A

Virust targets anterior horn motor neurons

82
Q

Antigenic shift

A
  1. Influenza A only
  2. Genetic reassortment
  3. Coinfection with 2 different strains of Influenza A with reasortment of segments of genome
  4. Produce new agent
  5. Pandemics
83
Q

Only naked RNA viruses

A
  1. Picornavirus
  2. Calicivirus
  3. Hepevirus
  4. Reovirus
84
Q

Genital HSV latent in

A

Sacral Nerve Ganglia

85
Q

Virion-associated polymerase carried by

A
  1. Reovirus
  2. Arenavirus
  3. Retrovirus
86
Q

Cytomegalic inclusion disease

A
  1. Jaundice
  2. Hepatosplenomegaly
  3. thrombocytic purpura (Blueberry muffin baby)
  4. Penumonitis
  5. CNS damage
87
Q

Hep A disease presentation

A

Mild acute

No chronic

No sequellae

88
Q

Rabies symptoms

A
  1. Flu-like
  2. Hydrophobia
  3. Seizures
  4. Disorientation
  5. Hallucination
  6. Coma
  7. Death
89
Q

Arboviruses are

A
  1. Togavirus encephalitis
  2. Flavivirus
  3. Bunyavirus
90
Q

EBV diseases

A
  1. Heterophile-positive mononucleosis, “kissing disease”
  2. Lymphoproliferative disease
  3. Hary oral leukoplakia
91
Q

What is found in DX of HPV

A

Koilocytic cells (cells with perinuclear cytoplasmic vacuolization)

92
Q

Negri bodies found in

93
Q

ROBA

A

Segmented RNA viruses

  • Reovirus
  • Orthomyxovirus
  • Bunyavirus
  • Arenavirus
94
Q

Common warts due to HPV are what serotypes

95
Q

Pol gene products

A
  1. Reverse transcriptase
  2. Integrase
  3. Protease
96
Q

Hep B intermediate replicative form

97
Q

In +RNA retrovirus mRNA transcribed from

A

dsDNA intermediate

98
Q

Herpesviridae viruses

A
  1. HSV
  2. VZV
  3. EBV
  4. CMV
  5. HHV-6
  6. HHV-8
99
Q

Herpesviridae features

A

Intranuclear inclusion bodies

Establishes latency

100
Q

Adenovirus diseases

A
  1. ARD and pneumonia
  2. Pharyngoconjunctivitis
  3. Epidemic Keratoconjunctivitis
  4. Acute hemorrhagic cystitis
  5. Gastroenteritis
101
Q

Mumps distinguishing characteristics

A

Single Hemagglutinin Neuraminidase glycoprotein and Fusion protein

102
Q

Adenovirus pathogenesis

A

Penton fibers act as hemagglutinin

103
Q

Gag gene products

A
  • Group-specifc antigens
  • p24
  • p7p9
  • p17
104
Q

Measles presentation

A

3 C’s

  1. Cough
  2. Coryza
  3. Conjunctivitis
105
Q

Hep C disease presentation

A

Acute is usually subclinical

Most chronic

Primary hepatocellular carcinoma, cirrhosis

106
Q

Coxsackie B disease

A
  1. Bornholm disease (Devils Grip)
  2. Aseptic meningitis
  3. Severe sytemic disease of newborn
  4. Myocarditis

Microbology (6 decks)

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