General principals Flashcards
Structural toxins
- Endotoxin
- Peptidoglycan
- Teichoic Acids
Anthrax toxin (LF) mode of action
Lethal factor
Endotoxin is
- Structural toxin
- LPS in G - cells outer membrane
- Toxic protion is Lipid A
- LPS activates macrophages leading to release of TNF-α, IL-1, and IL-6
cAMP inducres
- Heat labile toxin (LT)
- Cholera toxin
- Anthrax toxin
- Pertussis toxin
Diptheria toxin mode of action
ADP ribosyl transferase causing inactivation of eEF-2 inhibiting Protein synthesis
Exotoxin A mode of action
ADP ribosyl transferase inactivating eEF-2 inhibiting protein synthesis
Verotoxin mode of aciton
Shiga-like
Interferes with 60S ribosomal subunit
Primary mechanism of aherence in most G - cells
Pili/fimbriae
Anthrax toxin (EF) mode of action
Edema factor: adenylate cyclase
Cytolysins
Lyse cells from outside by damaging membrane
- C. perfringens alpha toxin: Lecithinase
- S. aureus α toxin: forms pores
Exotoxin A organism
Pseudomonas
Anthrax toxin (PA) mode of action
Protective antigen
Toxins that inhibit protein synthesis
- Diphtheria toxin
- Exotoxin A
- Shiga Toxin
- Verotoxin
Primary mechanism of aherence in G + cells
Teichoic acid
Heat labile toxin organism
ETEC
Shiga toxin mode of action
Interferes with 60S ribosomal subunit inhibiting Protein synthesis
Enterotoxic, cytotoxic, and neurotoxic
Verotoxin organism
EHEC
Pertussis toxin mode of action
ADP ribosylates Gi negative regulator of adynlate cyclase causing increased cAMP
Cholera toxin mode of action
Stimulates an Adenylate Cyclase by ADP ribosylation of GTP binding protein
Some Killers Have Pretty Nice Capsules
Bacteria with Capsule
Strep penumoniae
Klebsiella
Haemophilus influenzae
Pseudomonas
Neisseria meningitidis
Cryptococcus neoformans
Heat labile toxin (LT) mode of action
LT stimulates an Adenylate Cyclase by ADP ribosylation of GTP binding protein
