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Microbology > Mechanisms of Resistance to Microbial Infections > Flashcards

Mechanisms of Resistance to Microbial Infections Flashcards

1
Q

M. leprae protective mechanism

A

Th1 stimulation is protective (Leads to Tuberculoid form)

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2
Q

N. gonorrhoeae evasive mechanism

A

Antigenic variation of pili and OMPs

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3
Q

EBV evasive mechanism

A

Generalized immunosuppression

Produces molecule homologous to IL-10 (shuts down Th1)

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4
Q

Rubeola evasive mechanism

A

Decreases MHC 2 expression

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5
Q

Protective mechanism against all Enveloped viruses

A

Ab blocks receptor binding

C Lyses envelope

Ab and C enhance phagocytosis

Th1 cells stimulate CTLs and NK

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6
Q

Psuedomonas evasive mechanism

A

Inactivates C3a, C5a

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7
Q

TB evasive mechanism

A

Sulfatides inhibit phagolysosome formation

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8
Q

Hepatitis C evasive mechanism

A

Bloacks IFN-α and -β

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9
Q

Adenovirus evasive mechanism

A

Decreases MHC1 Expression

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10
Q

Herpes simplex 1 and 2 protective mechanism

A

Enveloped Virus

Antibody blocks receptor binding

C lyses envelope

Ab and C enhances Phagocytosis

Th1 cells stimulate CTls and Nk

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11
Q

Herpesviridae protective mechanism

A

Enveloped Virus

Antibody blocks receptor binding

C lyses envelope

Ab and C enhances Phagocytosis

Th1 cells stimulate CTls and Nk

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12
Q

Protective mechanism against all Naked Capsid viruses

A

Antibody blocks receptor binding and CMI destroys infected cells

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13
Q

Listeria evasive mechanism

A

Hemolysin disrupts phagosome membrane allows escape into cytoplasm

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14
Q

Hepatitis C protective mechanism

A

Enveloped Virus

Antibody blocks receptor binding

C lyses envelope

Ab and C enhances Phagocytosis

Th1 cells stimulate CTls and Nk

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15
Q

Hepatitis B protective mechanism

A

Enveloped Virus

Antibody blocks receptor binding

C lyses envelope

Ab and C enhances Phagocytosis

Th1 cells stimulate CTls and Nk

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16
Q

CMV protective mechanism

A

Enveloped Virus

Antibody blocks receptor binding

C lyses envelope

Ab and C enhances Phagocytosis

Th1 cells stimulate CTls and Nk

17
Q

Rhinovirus protective mechanism

A

Antbody blocks receptor binding causing CMI to destroy infected cells

18
Q

Rubeola protective mechanism

A

Enveloped Virus

Antibody blocks receptor binding

C lyses envelope

Ab and C enhances Phagocytosis

Th1 cells stimulate CTls and Nk

19
Q

Rhinovirus evasive mechanism

A

Antigenic drift

20
Q

TB protective mechanism

A

Th1 produces IFN-γ to make Angry Macrophages

21
Q

CMV evasive mechanism

A

Generalized immunosuppression

Decrease MHC 1 and 2 expression

Produces chemokine receptor and MHC1 homologues

22
Q

EBV protective mechanism

A

Enveloped Virus

Antibody blocks receptor binding

C lyses envelope

Ab and C enhances Phagocytosis

Th1 cells stimulate CTls and Nk

23
Q

Herpesviridae evasive mechanism

A

Nuclear membrane envelope is nonimmunogenic

24
Q

What bacteria destroys IgA as an evasive mechanism

A

IgA protease produces

  1. Strep. pneumoniae
  2. H. influenzae
  3. N. meningitidis
  4. N. gonorrhoeae
25
Q

Herpes simplex 1 and 2 evasive mechanism

A

Block TAP function (inhibits MHC 1 expression)

Viral glycoprotein decreases complement activation

26
Q

Adenovirus protective mechanism

A

Antibody blocks receptor binding and CMI destroys infected cells

27
Q

Strep pyogenes immune pathology

A

Exotoxins act as superantigens

Causes Type 2 and 3 HS

28
Q

S. aureus evasive mechanism

A

Protein A binds Fc of IgG and inhibits opsonization

29
Q

Borrelia burgdorferi immune pathology

A

Immune compleses cause rash, arthritits, and neurologic symptoms

30
Q

EBV immune pathology

A

Activates B cells causes production of heterophile Abs

31
Q

M. leprae evasive mechanism

A

Th2 stimulation results in lepromatous form

Microbology (6 decks)

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