Mechanisms of Resistance to Microbial Infections Flashcards
M. leprae protective mechanism
Th1 stimulation is protective (Leads to Tuberculoid form)
N. gonorrhoeae evasive mechanism
Antigenic variation of pili and OMPs
EBV evasive mechanism
Generalized immunosuppression
Produces molecule homologous to IL-10 (shuts down Th1)
Rubeola evasive mechanism
Decreases MHC 2 expression
Protective mechanism against all Enveloped viruses
Ab blocks receptor binding
C Lyses envelope
Ab and C enhance phagocytosis
Th1 cells stimulate CTLs and NK
Psuedomonas evasive mechanism
Inactivates C3a, C5a
TB evasive mechanism
Sulfatides inhibit phagolysosome formation
Hepatitis C evasive mechanism
Bloacks IFN-α and -β
Adenovirus evasive mechanism
Decreases MHC1 Expression
Herpes simplex 1 and 2 protective mechanism
Enveloped Virus
Antibody blocks receptor binding
C lyses envelope
Ab and C enhances Phagocytosis
Th1 cells stimulate CTls and Nk
Herpesviridae protective mechanism
Enveloped Virus
Antibody blocks receptor binding
C lyses envelope
Ab and C enhances Phagocytosis
Th1 cells stimulate CTls and Nk
Protective mechanism against all Naked Capsid viruses
Antibody blocks receptor binding and CMI destroys infected cells
Listeria evasive mechanism
Hemolysin disrupts phagosome membrane allows escape into cytoplasm
Hepatitis C protective mechanism
Enveloped Virus
Antibody blocks receptor binding
C lyses envelope
Ab and C enhances Phagocytosis
Th1 cells stimulate CTls and Nk
Hepatitis B protective mechanism
Enveloped Virus
Antibody blocks receptor binding
C lyses envelope
Ab and C enhances Phagocytosis
Th1 cells stimulate CTls and Nk
CMV protective mechanism
Enveloped Virus
Antibody blocks receptor binding
C lyses envelope
Ab and C enhances Phagocytosis
Th1 cells stimulate CTls and Nk
Rhinovirus protective mechanism
Antbody blocks receptor binding causing CMI to destroy infected cells
Rubeola protective mechanism
Enveloped Virus
Antibody blocks receptor binding
C lyses envelope
Ab and C enhances Phagocytosis
Th1 cells stimulate CTls and Nk
Rhinovirus evasive mechanism
Antigenic drift
TB protective mechanism
Th1 produces IFN-γ to make Angry Macrophages
CMV evasive mechanism
Generalized immunosuppression
Decrease MHC 1 and 2 expression
Produces chemokine receptor and MHC1 homologues
EBV protective mechanism
Enveloped Virus
Antibody blocks receptor binding
C lyses envelope
Ab and C enhances Phagocytosis
Th1 cells stimulate CTls and Nk
Herpesviridae evasive mechanism
Nuclear membrane envelope is nonimmunogenic
What bacteria destroys IgA as an evasive mechanism
IgA protease produces
- Strep. pneumoniae
- H. influenzae
- N. meningitidis
- N. gonorrhoeae
Herpes simplex 1 and 2 evasive mechanism
Block TAP function (inhibits MHC 1 expression)
Viral glycoprotein decreases complement activation
Adenovirus protective mechanism
Antibody blocks receptor binding and CMI destroys infected cells
Strep pyogenes immune pathology
Exotoxins act as superantigens
Causes Type 2 and 3 HS
S. aureus evasive mechanism
Protein A binds Fc of IgG and inhibits opsonization
Borrelia burgdorferi immune pathology
Immune compleses cause rash, arthritits, and neurologic symptoms
EBV immune pathology
Activates B cells causes production of heterophile Abs
M. leprae evasive mechanism
Th2 stimulation results in lepromatous form
