virus

Question 1

HIV virus is a RNA virus or DNA virus

Answer 1

RNA (retro-virus）/ single strand

Question 2

There are two subtype HIV virus (HIV-1 and HIV-2) which one is more abundant

Answer 2

HIV-1 / HIV-2 is less virulent and has a longer incubation time

Question 3

Which type of T-cell is the target of the HIV virus

Answer 3

CD4 cells

Question 4

During the replication process which enzyme is essential

Answer 4

RT

Question 5

List all classes of antiviral therapy

Answer 5

PI
NNRTI / NRTI
INTI

Question 6

what is the difference between neucleoside ans necleotide

Answer 6

neucleoside—sugar + base
neucleotide—phosphate + sugar + base

Question 7

for PI drug, they all end with

Answer 7

gravir

Question 8

explain what is IRIS syndrome

Answer 8

increased in CD4 cell level

Question 9

explain how NRTI works

Answer 9

target at
pro-drug (needs to be phospho

Question 10

explain how NNRTI works

Answer 10

inhibit NT activity

Question 11

explain how the resistance to NRTI deveolope

Answer 11

virus enzzyme that can no
RT—no longer recognoised the phosphorylated drug

Question 12

explain how

Answer 12

change in the binding site–resistanc

Question 13

why combintion therapy

Question 14

which drug should not be used when virus load > 100000

Answer 14

rilpivirine

Question 15

which gene is assocaited with hypersensitivity of abacavir

Answer 15

HLA-B* 5701

Question 16

list all the NRTIs

Answer 16

abacavir
lamivudine
zidovudine

Question 18

can HIV virus transmit via the milk

Answer 18

yes it can, hence, it is recommended that the patient should avoid breastfeeding

Question 19

any other factors that may influece the

Question 20

common cormobidities associated with HIV patient

Answer 20

osteoporosis

Question 21

which drug is a entry inhibitor

Answer 21

maraviroc

Question 22

all protease inhibitor end with

Answer 22

navir

Question 23

which drug is a fusion inhibior

Answer 23

enfuvirtide

Question 24

what is the issue associated with TB-HIV patient

Answer 24

hard to achieve the required level in order for us to see therapeitic effect

Question 25

common issues associated with HIV patient when aging

Answer 25

cormobodities—more drugs–prone to drug-drug interaction

obsesity

CVD

osteoporosis

liver disease

Question 26

describe PEP

Answer 26

should be taken within 72 hours of exposure
continue after 28 days
not recommended for non-ocxupational exposiure

Question 27

should intervention starts before knowing the drug resistence of the virus Y/N

Answer 27

Y

Question 28

what is PeEP for

Answer 28

it is for somone who does not have HIV but at a high risk of getting it

Question 29

TB-HIV can happen even if the patient has a normal CD4 cells count

Answer 29

Y

Question 30

when should we start the prophylaxis treatment for PJP in HIV patient

Answer 30

CD4 < 200

Question 31

Sx for PJP infection

Answer 31

fever
dry cough

Question 32

drugs for prophylaxis and treatment for PJP

Answer 32

trimethoprim
sulfamethoxazole