virus Flashcards
virus
HIV virus is a RNA virus or DNA virus
RNA (retro-virus）/ single strand
There are two subtype HIV virus (HIV-1 and HIV-2) which one is more abundant
HIV-1 / HIV-2 is less virulent and has a longer incubation time
Which type of T-cell is the target of the HIV virus
CD4 cells
During the replication process which enzyme is essential
RT
List all classes of antiviral therapy
PI
NNRTI / NRTI
INTI
what is the difference between neucleoside ans necleotide
neucleoside—sugar + base
neucleotide—phosphate + sugar + base
for PI drug, they all end with
gravir
explain what is IRIS syndrome
increased in CD4 cell level
explain how NRTI works
target at
pro-drug (needs to be phospho
explain how NNRTI works
inhibit NT activity
explain how the resistance to NRTI deveolope
virus enzzyme that can no
RT—no longer recognoised the phosphorylated drug
explain how
change in the binding site–resistanc
why combintion therapy
which drug should not be used when virus load > 100000
rilpivirine
which gene is assocaited with hypersensitivity of abacavir
HLA-B* 5701
list all the NRTIs
abacavir
lamivudine
zidovudine
can HIV virus transmit via the milk
yes it can, hence, it is recommended that the patient should avoid breastfeeding
any other factors that may influece the
common cormobidities associated with HIV patient
osteoporosis
which drug is a entry inhibitor
maraviroc
all protease inhibitor end with
navir
which drug is a fusion inhibior
enfuvirtide
what is the issue associated with TB-HIV patient
hard to achieve the required level in order for us to see therapeitic effect
common issues associated with HIV patient when aging
cormobodities—more drugs–prone to drug-drug interaction
obsesity
CVD
osteoporosis
liver disease
describe PEP
should be taken within 72 hours of exposure
continue after 28 days
not recommended for non-ocxupational exposiure
should intervention starts before knowing the drug resistence of the virus Y/N
Y
what is PeEP for
it is for somone who does not have HIV but at a high risk of getting it
TB-HIV can happen even if the patient has a normal CD4 cells count
Y
when should we start the prophylaxis treatment for PJP in HIV patient
CD4 < 200
Sx for PJP infection
fever
dry cough
drugs for prophylaxis and treatment for PJP
trimethoprim
sulfamethoxazole
