cholinergic receptor

Question 1

Ach =

Answer 1

choline + acetyl CoA

Question 2

Ach is positively charged Y/N

Answer 2

Y
can not cross the lipid membrane

Question 3

the enzyme that breaks down Ach

Answer 3

cholinesterase

Question 4

G protein for M1/M3/M5

Answer 4

Gq

Question 5

G protein for M2/M4

Answer 5

Gi

Question 6

Ach has the same selectivity for nicotinic and muscarnic receptors
Y/N

Answer 6

Y

Question 7

Add methyl groups will make it harder for the enzyme to break down Y/N

Answer 7

Y

Question 8

binding mechanism of Ach with nicotinic receptors

Answer 8

positvely charged N get trapped in the negatively charged aromatic ring

Question 9

drugs that acts on the enzyme acetylcholinesterase

Answer 9

neostigmine (stigmine)
donepezil

Question 10

drugs that acts on the enzyme acetylcholinesterase can be used to treat

Answer 10

alzheimer
myasthenia gravis
reverse the effect of muscle relaxants

Question 11

generally structure of muscarinic antagonist

Answer 11

N+ in one end (needs to be able to get protonated at physiology PH)
aromatic rings in the other ends (one to two rings are ok