antihistamine Flashcards
antihistamine
1
Q
three types of antihistamines
A
ethylene diamine / aminopropyl / aminoalkyl ether / tricyclic
2
Q
which one of them has the most potent anticholinergic effect
A
aminoalkyl ether
3
Q
which of them has the least sedative effect
A
aminopropyl
4
Q
which of them has the GI side effect
A
ethylene diamine
5
Q
which of them has the least CNS effect
A
ethylene diamine
6
Q
why substituted aromatic ring can not bind to the binding site (hydrophobic site)
A
Too bulky
7
Q
for tricyclic antihitamine, the two aromatic rings are in the same plane Y/N
A
N
8
Q
which structure would contribute to the anti-muscarinic effect
A
branched-CH3
9
Q
which structrure contribute to the cardiac toxicity
A
t-butyl
