Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Bacteriology > Virulence Factors > Flashcards

Virulence Factors Flashcards

1
Q

Mycobacteria tuberculosis

A
  • Serpentine cord formation (cord factor)
  • Mycolic acids prevent attack by lysozyme, complement
  • LAM: stimulates host cytokines, TNF, IL-6
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Mycoplasma pneumoniae

A
  • Proline-rich adhesion (adhere to cells)
  • Protein-M: block antibody
  • **Production of oxygen radicals
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Corynebacterium diphtheriae

A
  • AB toxin: B binds to receptor; A ADP-ribosylates EF-2 –> stop protein synthesis
  • High Fe will repress toxic effects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Bordetella pertussis

A
  • Filamentous hemaglutinin: phagocytosed in macrophages
  • Ciliary stasis of mucus escalator
  • AB toxin: ADP-ribosylates inhibitory G-protein –> increase in cAMP
  • Tracheal cytotoxin
  • LPS
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Haemophilus influenzae

A
  • LOS
  • IgA protease
  • **PRP capsule (type b)

Most symptoms from T-cell activation by PG and bacterial replication

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Legionella pneumophila

A
  • Type II and Type IV secretion
  • Activates macrophage coiling phagocytosis of bacterium
  • Prevent phagolysosome fusion
  • Release blebs of LPS
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

EPEC

A
  • Attachment protein

- inhibit water uptake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

ETEC

A
  • CFA adhesion pili
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

EHEC

A
  • Shiga-like toxin: AB toxin protein synthesis inhibitor (becomes systemic)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

EIEC

A
  • Invasive colonization factors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

EAEC

A
  • Aggregative pili –> infective foci
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Salmonella

A
  • Cytotoxic enterotxin

- Typhoid toxin: ADP-ribosylate G-protein; damage DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Shigella

A
  • Lyse phagolysosome and replicated in MQ (release IL-1)
  • Shiga enterotoxin disrupts protein synthesis
  • Spread via actin tails
  • Type III secretion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Yersinia pestis

A
  • Type III secretion
  • Inhibit MAP kinase (prevent cytokine production and cell replication)
  • Prevent phagocytosis
  • Prevent platelet aggregation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Vibrio cholerae

A
  • AB toxin: A with ADP-ribosylate G-protein to increase cAMP
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Vibrio parahemolyticus

A
  • Biofilms, T3SS, T6SS, hemolytic/cytotoxic enterotoxin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Vibrio vulnificus

A
  • Necrotizing cytotoxin, antiphagocytic capsule
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Campylobacter jejuni

A
  • Inflammatory enterotoxin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Campylobacter fetus

A
  • Inhibit complement fixation by C3b
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Helicobacter pylori

A
  • Bind base of mucosa
  • Bind O bloodgroup antigen
  • Urease buffer to raise pH
  • VacA: anion channel, vacuolation of epithelial cells, inhibit T cells
  • CagA (ulcers)
21
Q

Treponema pallidum

A
  • Hyaluronidase
  • Few surface proteins (hides)
  • Tertiary is a hyperimmune response
22
Q

Neisseria gonorrhea

A
  • Pili, Opa (antigenic variation)
  • Por (no phagolysosome fusion), Rmp (prevent Ab binding to other parts), IgA protease
  • **LOS
  • Fbp (scavenges Fe)
23
Q

Neisseria meningiditis

A
  • gonorrhea, plus…
  • Antiphagocytic capsule
  • Pili to cross BBB
24
Q

Chlamydia trachomatis

A
  • Invasiveness from elementary bodies
  • Inhibit phagolysosome fusion
  • Induce cytokines
25
Q

Borrelia recurrentis, hermsii

A
  • Antigenic variation (up and down fever)
26
Q

Borrelia burgdorferi

A
  • Doesn’t say much! No antigenic variation though
27
Q

Coxiella burnetti

A
  • Infects lung epithelia
28
Q

Ehrlichia, Anaplasma

A
  • Infect leukocytes
29
Q

Rickettsia

A
  • Grow in cytoplasm

- Endothelial pathogen

30
Q

Bacillus cereus

A
  • Emetic toxin

- Enterotoxins: hemolytic, non-hemolytic, cytotoxin

31
Q

Bacillus anthracis

A
  • AB toxin (A part has LF for MAP kinase protease and EF for making cAMP)
32
Q

Brucella

A
  • LPS, PG, cytokines (growth)

- Undulant fever due to release from macrophages

33
Q

Francisella tularensis

A
  • Grow in MQ and PMNs to high titer
  • Resist complement
  • LPS, PG
34
Q

Pasteurella multocida

A
  • **Antiphagocytic capsule
  • Pili, adhesion, Fe-binding
  • Crazy fast growth
35
Q

Bartonella hensleae

A
  • T4SS

- Stimulate apoptosis of cells

36
Q

Leptospria interrogans

A
  • No toxin (just LPS, PG)

- Damage to capillaries

37
Q

Staphylococcus aureus

A
  • PG, teichoic acids, Protein A (antigens)
  • Coagulase
  • Hyaluronidase, staphylokinase (tissue invasion)
  • Hemolysins: alpha and beta toxins, leukocidin (PVL)
  • Exfoliative toxin
  • TSST-1: superantigen
  • Enterotoxins (food poisoning)
  • Quorum sensing (biofilms)
38
Q

Streptococcus pyogenes

A
  • M protein (heart reactivity)
  • Antiphagocytic
  • Streptokinase (dissolves fibrin)
  • Streptdornase (DNAse)
  • Hyaluronidase
  • Exotoxins (scarlet fever, TSS)
  • Hemolysins
39
Q

Streptococcus pneumoniae

A
  • Tissue colonization

- IgA protease

40
Q

Listeria monocytogenes

A
  • Intracellular growth: internalin
  • Break out of phagolysosomes
  • Actin polymerization
41
Q

Pseudomonas aeruginosa

A
  • Adhesion pili
  • Persister strains
  • LPS
  • T3SS
  • Exotoxins A (EF-2) and S (signal apoptosis)
  • Elastase
  • Pyocyanin / pyochelin: toxic O2 radicals
42
Q

Bacteroides fragilis

A
  • Antiphagocytic

- Neuraminidase, heparinase

43
Q

Prevotella melaninogenica

A
  • Collagenase
44
Q

Clostridium botulinum

A
  • AB neurotoxin: B binds motor endplates; A block release of ACh by cleaving synaptobrevin (necessary for fusion of synaptic vesicle)
45
Q

Clostridium tetani

A
  • AB neurtoxin: retrograde transport and prevent GABA release
46
Q

Clostridium perfringens

A
  • Alpha-toxin: phopholipase for membranes
  • Hyaluronidase, collagenase
  • Beta-toxin for enteritis necroticans
  • Enterotoxin sometimes (like B. cereus)
  • Gas from fermentations
47
Q

Clostridium difficile

A
  • Toxin A: enterotoxin; fluid accumulation

- Toxin B: cytotoxin; kill gut epithelial cells

48
Q

Aeromonas hydrophila, Plesiomonas shigelloides

A
  • LPS, PG (typical G-)
  • ACT toxin (lyse cells, increase cAMP)
  • Pili to attach to gut epithelium

Bacteriology (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions