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Micro & Immuno > Virology > Flashcards

Virology Flashcards

1
Q

Inclusion bodies in biopsy

Dx?

A

Almost always viral

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2
Q

Small non-env DNA virus that attacks erythroid cell surface receptors

A

MC seen in SCA

Parvo B19

Giant pronormoblast w glassy intranuclear inclusion

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3
Q

Marker for acute HBV

A

HBsAg

HBeAg

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4
Q

Marker for HBV acute infection but aSx

A

Anti-HBc IgM

Window phase

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5
Q

Marker for HBV for cleared infection / vaccination

A

Anti HBs

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6
Q

Chronic HBV marker

A

Anti HBe
HBs Ag
HBV DNA

Dec viral replication n infectivity

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7
Q

Acute + chronic HBV marker

A

Anti HBc I

IgG

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13
Q

HBV serological markers

A

HBsAg : HBV surface glycoproteins.
acute infections
>6 months = chronic infection

HBeAg
HBV polypeptide
acute infection
Indicates ↑ viral replication & infectivity

Anti-HBc IgM
First sign of acute infection
Present during window phase prior to HBsAg & HBeAg

Anti-HBs
Seen with cleared infection or vaccination
Confers long-term immunity

Anti-HBe
Develops in cleared infection & later in chronic infection
Indicates ↓ viral replication & infectivity

Anti-HBc IgG
Present in both acute & chronic infection
Not present after vaccination

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14
Q

Maculopapular rash on chest n trunk after fever subsides

A

Roseola

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15
Q

Latex agglutination Dx for?

A

Rotavirus

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16
Q

Receptors used by viruses

Integrins (heparan sulfate):

CD21:

CD4, CXCR4, CCR5:

P antigen on RBCs:

Nicotinic ACh:

ICAM-1:

A

Integrins (heparan sulfate): CMV

CD21: EBV

CD4, CXCR4, CCR5: HIV

P antigen on RBCs: ParvoB19

Nicotinic ACh: Rabies

ICAM-1: Rhinovirus

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17
Q

Virus replicating in birds n passed to mosquitoes

A

West Nile

Culex

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18
Q

Virus causing Parkinsonian Sx

A

West Nile virus

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19
Q

Antigenic variation seen in?

A
  1. Influenza

2. HCV

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20
Q

MOA EBV

A
  • infects B cells : binds to CD21 surface receptors - activates CD8 cytotoxic cells via APC on MHC I - which destroys virus infected cells
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21
Q

Infectious mechanism of HDV

A

Complementation

HDV virus w/ nonfunctional protein complemented by HBV by “borrowing” HBV functional protein

  • superinfection
22
Q

Hearing loss, white pupils and PDA in infant. Dx?

A

Congenital rubella

o Sx:

  • cataracts
  • microcephaly, intellectual disability
  • PDA, Pulm stenosis
  • deafness

o Tx: Live vaccine 15m + 4-6 y/o both children + non-pregnant childbearing age women who don’t have Ab against rubella

23
Q

Hearing loss, white pupils and PDA in infant. Dx?

A

Congenital rubella

o Sx:

  • cataracts
  • microcephaly, intellectual disability
  • PDA, Pulm stenosis
  • deafness

o Tx: Live vaccine 15m + 4-6 y/o both children + non-pregnant childbearing age women who don’t have Ab against rubella

Micro & Immuno (8 decks)

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