Virology 2

Question 1

Congenital zika virus targets which cell type?

Answer 1

Neural progenitor cells

Question 2

Congenital zika virus clinical features?

Answer 2

1. Microcephaly, craniofacial disproportion
2. Neurologic (seizures, abnormalities)
3. Ocular

Question 3

Congenital zika virus Neuroimaging:

Answer 3

Calcifications, ventriculomegaly, cortical thinning

Question 4

Congenital rubella can be prevented by?

Answer 4

Preconception immunization of mother

Question 5

Rubella vs rubeola rash?

Answer 5

Rubella rash spreads faster than measles and donot darken or coalesce

Question 6

Only RNA virus that replicates in the nucleus

Answer 6

Influenza virus

Question 7

Rabies virus travel to brain. How?

Answer 7

Post synaptic ACh nicotinic receptors > retrograde through motor neurons > anterior horn > dorsal root ganglion > brain

Question 8

Ambisense?

Answer 8

Can act as both + and - sense RNA virus

Arena virus

Question 9

Test for HIV in neonates?

Answer 9

HIV RNA or DNA amplification tests

Question 10

sustained viriologic response (SVR)

Answer 10

HCV RNA not detected by PCR for 6 months after stopping treatment

Question 11

Which anti retro viral is mitochondrial toxin?

Answer 11

NRTI’s

Question 12

HIV associated encephalopathy histology?

Answer 12

Microglial nodules and multinucleated giant cells

Question 13

HIV associated dementia pathology?

Answer 13

HIV doesnot directly infect neurons. underlying pathology is from release of neurotoxic compounds by these activated macrophages.