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Virology 1 Flashcards

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1
Q

Viruses containing reverse transcriptase

A

Hepadna

retro virus

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2
Q

Circular DNA viruses

A

Hepadna
papilloma
polyoma

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3
Q

Unilateral middle ear effusion shows?

A

Eustachian tube blockade by nasopharyngeal carcinoma

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4
Q

In contrast to toxoplasmosis brain lesion in JC virus is?

A

Non-Enhancing multifocal

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5
Q

Parvo virus B19 infects which cells?

A

RBC precursors

Endothelial cells

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6
Q

Pronormoblast is?

A

several times larger than surrounding RBCs, with glassy, intranuclear viral inclusions.

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7
Q

Pronormoblast is formed by?

A

infection of progenitor RBCs with Parvo virus B19

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8
Q

Recent Parvo virus B19 infection is confirmed by?

A

anti-B19 IgM in serum

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9
Q

Meningitis is caused by which HSV?

A

HSV 2

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10
Q

HSV 1 infects the temporat lobe by entry through?

A

Olfactory tract to olfactory cortex in medial temporal lobe

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11
Q

Most common reason for hospitalization in children with HSV-1 gingivostomatitis is?

A

Dehydration (refusal to drink)

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12
Q

Neonatal HSV (fever and seizures in newborn period) caused by?

A

HSV-2

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13
Q

Severity of recurrence in HSV, Why?

A

Less severe, due to humoral immunity

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14
Q

HSV patient is more contagious during?

A

Recurrance

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15
Q

Difference in painful vesicular rash b/w HSV and VZV?

A

HSV: Bilateral
VZV: Unilateral, in dermatome without systemic involvement

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16
Q

Docosanol?

A

Topical agent for herpes labialis, prevents viral entry.

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17
Q

HSV diagnosed by?

A
  1. PCR of CSF
  2. Tzank smear
  3. Direct fluorescence antibody
18
Q

Herpes zoster oticus

A

Ramsay hunt syndrome

Facial nerve involvement: Bell’s palsy, ear pain, vesicles in external auditory meatus

19
Q

Hemorrhagic inflammation of dorsal root ganglion and peripheral nerve is caused by?

this leads to?

A

Reactivation of VZV

neuropathic pain: herpetic neuralgia

20
Q

Capsaicin topical form. MOA?

A

Activation of TRPV1→ substance P depletion and long standing dysfunction of nociceptive nerve fibers (build up of intracellular Ca→ Dysfunctionalization of nociceptive nerve fibers)

21
Q

Primary CNS lymphoma ; most common subtype?

A

Diffuse large B-cell

22
Q

Oncogenic viral proteins of EBV?

their purpose?

A

EBNA-1 LMP-1
used by virus to keep remain latent in memory B cells to prevent from apoptosis. This also converts premalignant lesion into nasopharyngeal cancer

23
Q

Monospot test is negative in initial EBV infection, what should we do next?
What else it suggests

A

Repeat it

CMV is possible cause of IM

24
Q

Blueberry muffin rash is due to underlying…

A

thrombocytopenia

Extramedullary hematopoiesis

25
Q

CMV remains latent in?

A

Mono-nuclear cells (B, T lymphocytes and Macrophages)

26
Q

Highest risk g congenital CMV in?

A

2nd trimester

27
Q

Roseola Infantum (Exanthem subitum) infects which cells?

A

CD4 T cells

28
Q

Most common tumor in HIV+ patients?

A

Kaposi sarcoma

29
Q

Atypical lymphocytes are………. by virus. They ………. to infected cells.

A

not infected, react

30
Q

All positive sense RNA viruses are icosahedral, except?

A

Corona virus

31
Q

Herpangina:
Caused by?
Presentation?

A

Coxsackie Virus
Fever + Herpes like but spares anterior mouth and involves posterior pharyngeal wall, tongue, soft palate.
Vesicles without rash.

32
Q

Coxsackie Virus
oral ……….
skin ……….

A

Enanthem

Exanthem

33
Q

All -ve sense RNA virus has? (capsid symmetry)

34
Q

Paramyxo viruses contain protein F (fusion) that causes………. to fuse and form…….?

A

respiratory epithelial cells,

multinucleated cells

35
Q

Bronchiolitis: Cause?

Presentation?

A

RSV
♦ Antecedent 1. nasal congestion/discharge 2. Cough
♦ 1. Diffuse wheeze/crackles 2. Respiratory distress (tachypnea, retractions, nasal flaring)

36
Q

Pertussis lung auscultation?

A

Clear to auscultate

37
Q

Classic dengue fever presentation?

A
  1. Flu like
  2. myalgias & joint oain
  3. retro porbital pain
  4. Rash (white islands in red sea)
38
Q

Secondary infection with different strain of dengue presentation?

A
  1. Maculopapular rash
  2. Multiple pruritic lesions
  3. Hepatomegaly
  4. Thrombocytopenia, leukopenia
39
Q

Dengue hemorrhagic fever underlying cause?

A
  1. ↑ vascular permeability (main cause)
  2. thrombocytopenia <100,000
  3. Spontaneous bleeding → shock
40
Q

Yellow fever liver biopsy?

A

Councilman bodies (eosinophilic apoptotic globules)

Points I Forget (12 decks)

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