Virology Flashcards

1
Q

Name the three domains of living organisms

A

Eubacteria
Archaea
eukaryota

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2
Q

Name the 2 succesful cellular plans of organization

A

Eukaryotes
Prokaryotes

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3
Q

Distinguish between Eukaryotes and prokaryotes

A

Distinguished by the size and the type of internal structure
Eukaryotes
.A typical eukaryotes cells consists of
-Nucleus and chromosomes
-cell wall
-Organelles
-cytoskeleton
-Reproduce sexually
-Larger cells

Prokaryotes
.A typical prokaryote Cell:
-lack membrane bound organelles
-Naked DNA- no chromosomes
-Little/no internal compartmentation
-Reproduce by binary fission

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4
Q

Describe the basic structure of a virus.

A

-Genetic material(DNA or RNA)
-a protein Shell(capsid)
-lipid envelope(sometimes)

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5
Q

What is a virion and what is the function of the virion?

A

-This are fully assembled viral particles.
-Serve to protect the genome and transfer it to other calls

(virus outside a host cell)

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6
Q

Give the different viral genome type.

A

DNA or RNA

DNA
-dsDNA
-SSDNA

RNA
-dsRNA
-ssRNA

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7
Q

Different types of Viral genomes

Howthey are shaped

A

Linear
Circular
Segmented

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8
Q

Name the 2 type of symmetry formed between capsomers

A

Cubical
Helical

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9
Q

Classify varuses
Sub-family
Order
Family
Genus
Species

A

Order Nidovirales
Family Coronaviridae
Sub-Family Orthocoronavirinae
Genus Betacoronavirus
Species ? 2019 novel coronavirus

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10
Q

Local vs systemic infection

A

Localised infection means in one part of the body.

systemic/disseminated infection means infection is in the whole body.

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11
Q

Viral tropism

A

Viral tropism refers to the specific cells, tissues, or organs that a virus targets and infects within a host organism.

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12
Q

Viral dissemination

A

Viral dissemination refers to the spread of viruses from their initial site of infection to other parts of the body, often through the bloodstream, lymphatic system, or neural pathways.

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13
Q

Viral pathogenesis

A

Viral pathogenesis refers to the process by which viruses cause disease within a host organism

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14
Q

Acute infection

A

Virus eliminated in a predictable period

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15
Q

Persistent and latent infection

A

Persistence- Virus active for months or years
Latent- virus resides in cells in inactive state, for life, can reactivate.

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16
Q

Routes of entry of disease

A

Ingestion
Inhalation
Inoculation
Contact(incl. sexual)
Blood organ t/plant
Congenital/vertical

17
Q

Asymptomatic infections are related to…

A

Pathogenecity

18
Q

Symptomatic infection are related to…

A

Virulence

19
Q

No foothhold are related to…

A

infectivity

20
Q

Define Basic reproductive ratio

A

This is the number of secondary cases that will arise following the primary case if the pathogen is introduced into a susceptible population.

21
Q

Define attack rate

A

The number of ill cases/number of individuals exposed

22
Q

List the determinants of infectivity

A

.Route of transmission
.Amount of virus shed/Viral load
.Duration of viral shedding
.Host susceptibility

23
Q

Define pathogenecity

A

Ability of the pathogen to cause disease

24
Q

Define Virulence

A

measure of severity of disease once disease occurs

25
Q

What determines prevalence of a virus

A

Infectivity
Population immunity
Duration/Chronicity of the infection

26
Q

Define Seroprevalence

A

Prevalence of population with antibody against a particular pathogen

27
Q

Define the following words which relate to pattern of viral disease, Sporadic, Endemic, Epidemic, Pandemic.

A

Sporadic-Disease rare, only occasional cases, risk of infection low for nonimmune
Endemic- Disease common, constantly high number of new cases reported
Epidermic- Disease usually rare but suddenly many new cases occurring.
Pandemic- Common disease of worldwide proportion

28
Q

How to prevent viral diseases.

A

.Vaccines
.Alter host behavior
.Control/eliminate vectors
.Control spreading/epidemics
.Prophylaxis