Spleen and non-neoplastic lymph nodes

Question 1

Classify and discuss the causes of splenomegaly

Answer 1

Causes:
.Congestion- Persistence elevation of the splenic venous blood pressure

.infection- can either be, sytemic infection, bacterial infection, viral diseases, chronic malarial infection, granulomatous inflammation.

.Immune disorders- Rheumatoid arthritis and sytstemic lupus erythematosus

.Red blood cell abnormalities- Sickle cell anemia and hereditary spherocytosis

.Primary or metastatic neoplasms-

.Storage disorders

.Amyloidosis

Question 2

Discuss the pathological features of splenomegaly

Question 3

Hypersplenism- state the definition and list the treatment

Answer 3

Defined as an association between a peripheral blood pancytopaenia and splenic enlargement

treatment

Question 4

List infective and non-infective causes of necrotizing lymphadenitis

Answer 4

Infective disorders
.Lymphogranuloma venereum
.Cat scratch disease

Non-infective disorders
.Kikuchi’s disease
.Systemic lupus erythematosus

Question 5

List the infective and non infective causes of reactive lymphadenitis

Question 6

list the infective causes and non infective causes of granulomatous lymphadenitis.

Answer 6

Infective Disorders
.Mycobacterial infection- e.g. Mycobacterial Tuberculosis
.Toxoplasmosis

Non-infective Disorders
.Sarcoidosis
.Crohn’s disease
. reaction to tumour antigen
.Foreign body reaction