Viro: Bunyaviridae

Question 1

How many viruses does bunyaviridae have?

Answer 1

350 member viruses

Question 2

Transmission of Bunyaviridae

Answer 2

● Through arthropods
● In some rats/ rodents

Question 3

Genome of Bunyaviridae

Answer 3

● ssRNA
● Enveloped; segmented negative-sense,
single-stranded RNA

Question 4

Segment that encodes the RNA-dependent RNA
polymerase

Answer 4

Large

Question 5

Segment that encodes polyprotein processed
to form glycoproteins Gn and Gc

Answer 5

Medium

Question 6

Segment that encodes the nucleoprotein (N) or
nonstructural proteins (NSc)

Answer 6

Small

Question 7

T/F: Bunyaviridae has virions that has glycoprotein spikes but not matrix protein in their envelope.

Answer 7

True

Question 8

Where do bunya replicate?

Answer 8

Cytoplasm

Question 9

Prevention of bunyaviridae?

Answer 9

Inactivated vaccine for hantaan virus, others none

Question 10

Important genera of Bunyaviridae

Answer 10

1. Orthobunyavirus
2. Hantavirus
3. Nairovirus
4. Phlebovirus
5. Tospovirus

Question 11

Genera: arthropod-vertebrate-arthropod
cycle

Answer 11

Orthobunyavirus, Nairovirus , Phlebovirus

Question 12

Genera: vertebrate-vertebrate cycles without
arthropod vectors (disseminated by rodents)

Answer 12

Hantavirus

Question 13

Genera: transmited between plants by thrips

Answer 13

Tospovirus

Question 14

This genera is not athropod-borne; several are zoonotic.

Answer 14

Hantavirus

Question 15

Persistent infection of hantavirus:

Answer 15

Persistent infecton in rodent reservoir hosts

Question 16

Inapparent infection of hantavirus:

Answer 16

Inapparent infecton with virus shedding in saliva, urine
and feces

Question 17

Transmission of Hantavirus:

Answer 17

Transmission to humans through direct contact; of rodents

Question 18

Hantavirus causes diseases like:

Answer 18

Causes Hemorrhagic fever with renal syndrome
(HFRS)/ Old World and Hantavirus Pulmonary
Syndrome/ New world

Question 19

What are the viruses found under Hemorrhagic Fever with Renal Syndrome (Old World):

Answer 19

○ Hantaan Virus – inactvated vaccine available
○ Dobrava-Belgrade Virus
○ Seoul Virus
○ Puumala Virus

Question 20

What are the viruses found under Hantavirus Pulmonary Syndrome (New World)

Answer 20

○ Sin Nombre Virus
○ New York Virus
○ Black Creek Canal Virus
○ Bayou Virus
○ Andes Virus

Question 21

Clinical signs of Pulmonary Syndrome (New World)

Answer 21

Fever, myalgia, headache, nausea, vomitng,
nonproductve cough, shortness of breath

Question 22

Nairobi Sheep Ds. and Crimean-Congo hemorrhagic fever belongs to what genus?

Answer 22

Nairovirus

Question 23

Nairobi Sheep Ds. is enzootic to and targets what animals?

Answer 23

Enzootic in Eastern Africa; targets sheeps and goats

Question 24

What parasite transmits Nairobi Sheep?

Answer 24

Rhipicephalus
appendiculatus ticks (all stages)

Question 25

Transmission of Nairobi Sheep Disease is by?

Answer 25

via transovarial and trans-stadial transmission

Question 26

Clinical signs of Nairobi Sheep Disease

Answer 26

High fever, hemorrhagic enteritis, prostration, abortions in pregnant ewes; mortality up to 90%.

Question 27

What is the tick control of Nairobi Sheep Disease called?

Answer 27

Acaricides

Question 28

Crimean-Congo hemorrhagic fever virus is enzootic in?

Answer 28

Enzootic from western China to Africa, Eastern Europe, Middle East, and Central Asia

Question 29

Host of Crimean-Congo hemorrhagic fever virus

Answer 29

Domestic animals (sheep, goats, cattle)

Question 30

What tick transmits Crimean-Congo hemorrhagic fever virus

Answer 30

Hyalomma via transovarial and trans-stadial; also direct contact with infected animals or humans.

Question 31

Crimean-Congo hemorrhagic fever virus disease in humans signs:

Answer 31

Severe hemorrhagic fever; symptoms include high fever, myalgia, bleeding, liver necrosis, CNS damage; case-fatality rate 15–40%.

Question 32

T/F: Crimean-Congo hemorrhagic fever virus can be transmitted to human-to-human?

Answer 32

True

Question 33

This genus generally cause arthrogryposis, hydranencephaly; transmitted by mosquitoes.

Answer 33

Orthobunyavirus

Question 34

Akabane, Schmallenberg, Cache Valley, and La Crosse virus are found in what genus?

Answer 34

Orthobunyavirus

Question 35

Virus that causes tetratogenic effects/congenital defects

Answer 35

Akabane Virus

Question 36

Clinical sign of Akabane virus?

Answer 36

Pregnant ruminants undergo abortion and offspring has defects (brain abnormalities, muscle dystocia)

Question 37

Arthropods of Akabane virus

Answer 37

Aedes spp. And culex mosquitos (jappan), colicoides or biting midges (australia)

Question 38

Schmallenberg virus are caused by what parasites?

Answer 38

Caused by culicoides/ midges

Question 39

Schmallenberg Virus affects what animals?

Answer 39

Ruminants

Question 40

Schmallenberg Virus causes what?

Answer 40

causes deformities (musculo-skeletal deformities)

Question 41

Arthropod of Cache Valley Virus

Answer 41

Mosquito borne

Question 42

Rif Valley Fever virus is found in what genus?

Answer 42

Phlebovirus

Question 43

Rif Valley Fever virus arthropod?

Answer 43

Aedes spp. other species of mosquitoes

Question 44

Hosts of Rif Valley Fever virus

Answer 44

Hosts: Humans, Sheep, Goats, Cattles