Bacte Lec: Chlamydia Flashcards
Characteristic of Chlamydiae?
Non-motile, Gram-negative, pleomorphic, obligate intracellular parasite
Causes avian chlamydiosis and bovine abortion and psittacosis in humans
Chlamydophila psittaci
Recovered from cattle and sheep with various diseases including sporadic bovine encephalitis, infectious polyarthritis, pneumonia and diarrhea
Chlamydophila pecorum
Causes enzootic abortion of sheep and goats, chlamydial abortion in cattle, pigs and goats
Chlamydophila abortus
Causes intestinal infections in pigs
Chlamydophila suis
Causes Inclusion conjunctivitis in guinea pigs
Chlamydophila caviae
Cause of a variety of respiratory infections in humans. Similar organisms recovered from horses with respiratory infections and koalas with conjunctivitis
Chlamydophila pneumoniae
Causes Conjunctivitis (feline pneumonitis)
Chlamydia felis
How many serovar does Chlamydophila pneumoniae
have?
One serovary
T/F: Chlamydia trachomatis
has one serovar.
False: Many serovars; More than 15 serovars
Causes trachoma, inclusion conjunctivitis in infants, lymphogranuloma venereum, other genital tract infections, and proctitis in humans.
Chlamydia trachomatis
Respiratory infections in mice
Chlamydia muridarum
T/F: Chlamydia only have DNA.
Chlamydia have both RNA, DNA and cell walls like Gram negative bacteria.
Chlamydia is capable of hydrolyzing what substances?
Metabolically capable of hydrolyzing glucose, pyruvate and glutamate
Chlamydia exists in what stages?
Infectious & intracytoplasmic forms
Form of Chlamydia shows elementary odies.
Infectious form
Form of Chlamydia shows reticulate bodies
Intracytoplasmic form
Shape and size of elementary bodies.
Spherical shape and 0.25 um in diameter.
It is the dormant phase. Elementary bodies before uptake by target cell
Phase 1
Elementary bodies have very little metabolic activity during this time
Phase 1
What phase does this happen: Induction of metabolic activities with elementary bodies
Phase 2
What phase is Characterized by transformation of elementary bodies into non-infectious
Phase 3
What phase is characterized by reversion of the mature reticulate bodies back into elementary bodies which occurs within 20 to 30 hours after replication
Phase 4
All chlamydiae share a ________ antigen?
All chlamydiae share a genus-specific antigen
What type of antigen is used in complement fixation?
lipopolysaccharide (LPS) antigen used in complement fixation
The reactive component of LPS
Its reactive moiety is ketodeoxyoctanoic acid (KDO).
T/F: Toxins not demonstrated in Chlamydia, the lipid A portion of the LPS does not have endotoxic properties
True
Elementary bodies produce this, while reticulate bodies do not.
Hemagglutininins
Chlamydia infect what part of the body
mucous membranes of the respiratory system and gastrointestinal tracts of normal animals including avian species
Where are elementary bodies shed?
Elementary bodies are shed in secretions and feces in small number from asymptomatic animals
T/F: Chlamydia do not survive for long periods.
False: Chlamydiae can survive for long periods in the soil and feces
Factor that degrades the host transcription factors associated with the production of major histocompatibility complex molecules (MHC)
Chlamydial protease activity factor (CPAF)
What is the stained used in demonstration of organism?
Giemsa and Gimenez
T/F: Enzyme-linked Immunosorbent Assay is used for antigen detection in feces
True
Enzootic abortion is sheep and goats mode of infection.
Ingestion
SBE means?
Sporadic Bovine Encephalomyelitis
Chronic form of SBE exhibits?
fibrinous pericarditis, pleuritis and peritonitis
Morbidity and mortality of SBE?
50%
For smear, culture, and histopathology in SBE. What part of the body is used?
Brain is used, have fresh and half formalinized
Disease of chlamydia characterized by follicular conjunctivitis with ocular discharge that may become purulent
Feline Pneuomintis caused by C. felis
In feline pneuomintis ocular form is seem most commonly in what age?
Ocular form seen most commonly in 5-12 week old kittens
Chlamydial infections in koalas causes?
Conjunctivitis
Chlamydial infections in horses causes?
Respiratory infection
In humans, __% of C. psittaci caused by exposure to _____
70%; exposure to caged pet birds
