Virial McVirusface

Question 1

which types of hep can be immunised against

Answer 1

a and b

Question 2

what is pegferon alpha used for

Answer 2

initial hep B treatment or people with hep b and HIV where the HIV does not require antiretroviral treatment at present

also used in combo for hep c

Question 3

in the treatment of hep C what risk is associated with triple therapy

Answer 3

anaemia

neutropenia also occurs with these drugs - particularly containing borceprevir

Question 4

for which hep drug are muscle effects and perihperal neuropathy a risk

Answer 4

telbivudine (neucleoside analogue)

Question 5

which hep drug needs loads of contraception (avoid preg for 4 months in women and 7 months in men)

Answer 5

ribavirin

Question 6

if patient on telaprevri develops a rash would you stop treatment

Answer 6

not if mild to moderate - stop if deterioration

Question 7

at what age does chickenpox not need treatment as usually mild

Answer 7

1 month to 12 years

Question 8

when should antiretrovirals be started for chicken pox in adults

Answer 8

24 hours of start of rash

for 10 days with at least 7 days parentally if immunocompromised

Question 9

what is used for high risk people who are exposed to cheicken pox for prophylaxis

Answer 9

varicella zoster immunoglobulin

Question 10

what is the the difference between varicella zoster and herpes zoster

Answer 10

herpes zoster is shingles

varicella is chicken pox

Question 11

what is used to treat cytomeglovirus

Answer 11

gancyclovir- more effective but more powerful than aciclovir

Question 12

which herpes antiviral is associated with neurological reactions

Answer 12

valaciclovir

Question 13

what count is used to determine when to start antiretroviral treatment in HIV

Answer 13

CD4

Question 14

what is the regieme of choice for HIV (by drug class)

Answer 14

2 x neucleoside reverse transcriptase inhibitors
and either
non-neucleotide reverse transcriptase inhibitor
or
bosted protease inhibitor
or
integrase inhibitor

Question 15

should HIV positive mothers breastfeed

Answer 15

no - transmission risk

Question 16

what class of HIV anitretravirals have greatest interaction risk

Answer 16

protease inhibitors - all end in vir and interact with CYP

e.g. rotinavir

Question 17

what subtype are non-nucleotide reverse transcriptase ihibtiors avctive against

Answer 17

only HIV -1

Question 18

how can transient psychiatric distrubances produced but efavirenz (NNRTI) be reduced

Answer 18

take the dose at bedtime

Question 19

what are the metobolic effects of HIV treatment termed

Answer 19

lipidodystrophy syndrome

- fat redistribution, insulin resistance and dyslipidaemia

Question 20

bone risk associated with prolonged antiretroviral therapy

Answer 20

oesteonecrosis

Question 21

waht HIV drug is associated with life threatening hepatic effects

Answer 21

nevirapine

Question 22

two drugs most effectivce in treatment of flu

when are they licensed for

Answer 22

oseltamir and zanamivir - within the first hours of symptom onset

licesed for used for up to 48 hours of the first symptoms

Question 23

for prophylaxis when should oseltamivir and zanamivir be used

Answer 23

oseltamivir - 48 hours
zanamivir - 36 hours
within this many hours of exposure

Question 24

who should be given post flu exposure prophylaxis

Answer 24

people at high risk who are living in long term resistendial homes

high risk is over 65 or
COPD/HD/CDK/liver idsease/neurological disease/immunosupression/diabetes

and pregnant women