Virial McVirusface Flashcards
which types of hep can be immunised against
a and b
what is pegferon alpha used for
initial hep B treatment or people with hep b and HIV where the HIV does not require antiretroviral treatment at present
also used in combo for hep c
in the treatment of hep C what risk is associated with triple therapy
anaemia
neutropenia also occurs with these drugs - particularly containing borceprevir
for which hep drug are muscle effects and perihperal neuropathy a risk
telbivudine (neucleoside analogue)
which hep drug needs loads of contraception (avoid preg for 4 months in women and 7 months in men)
ribavirin
if patient on telaprevri develops a rash would you stop treatment
not if mild to moderate - stop if deterioration
at what age does chickenpox not need treatment as usually mild
1 month to 12 years
when should antiretrovirals be started for chicken pox in adults
24 hours of start of rash
for 10 days with at least 7 days parentally if immunocompromised
what is used for high risk people who are exposed to cheicken pox for prophylaxis
varicella zoster immunoglobulin
what is the the difference between varicella zoster and herpes zoster
herpes zoster is shingles
varicella is chicken pox
what is used to treat cytomeglovirus
gancyclovir- more effective but more powerful than aciclovir
which herpes antiviral is associated with neurological reactions
valaciclovir
what count is used to determine when to start antiretroviral treatment in HIV
CD4
what is the regieme of choice for HIV (by drug class)
2 x neucleoside reverse transcriptase inhibitors
and either
non-neucleotide reverse transcriptase inhibitor
or
bosted protease inhibitor
or
integrase inhibitor
should HIV positive mothers breastfeed
no - transmission risk
what class of HIV anitretravirals have greatest interaction risk
protease inhibitors - all end in vir and interact with CYP
e.g. rotinavir
what subtype are non-nucleotide reverse transcriptase ihibtiors avctive against
only HIV -1
how can transient psychiatric distrubances produced but efavirenz (NNRTI) be reduced
take the dose at bedtime
what are the metobolic effects of HIV treatment termed
lipidodystrophy syndrome
- fat redistribution, insulin resistance and dyslipidaemia
bone risk associated with prolonged antiretroviral therapy
oesteonecrosis
waht HIV drug is associated with life threatening hepatic effects
nevirapine
two drugs most effectivce in treatment of flu
when are they licensed for
oseltamir and zanamivir - within the first hours of symptom onset
licesed for used for up to 48 hours of the first symptoms
for prophylaxis when should oseltamivir and zanamivir be used
oseltamivir - 48 hours
zanamivir - 36 hours
within this many hours of exposure
who should be given post flu exposure prophylaxis
people at high risk who are living in long term resistendial homes
high risk is over 65 or
COPD/HD/CDK/liver idsease/neurological disease/immunosupression/diabetes
and pregnant women
