Fungal infections

Question 1

what is the treatment of choice for aspergillosis

Answer 1

voriconazole

Question 2

what is prescribed systemically for thrush if its resistance to fluconazole (vag or mouth)

Answer 2

itraconazole

Question 3

who are cryptococcosis and histoplasmosis common in?

what is the treatment of choice?

Answer 3

immunocompromised/HIV
amphotericin
can you itracon for histoplasmosis for non HIV pt

Question 4

what is the treatment for tinea captidis

Answer 4

griusulfulvin

Question 5

what do we use for empirical treatment of serious fungal infections in compromised paitents

Answer 5

amphotericin

Question 6

what type of antifungal is fluconazole

Answer 6

triazole

Question 7

what type of antifungal is clotrimazole

Answer 7

imidazole

Question 8

what type of antifuncal is ketoconazole

Answer 8

imidazole

Question 9

why is fluconazole used more commonly that intraconazole?

what class are they both

Answer 9

less likely to cause hepatotox

triazoles

Question 10

can nystatin or amphotericin be given by mouth

Answer 10

no - both are poorly absorbed

there are polyene antifungals

Question 11

amphotericin is highly protein bound and sideeffects are common, what can be done about this

Answer 11

use lipid formulation

Question 12

anidulafungin, caspofungin and micafungin are echinocandin antifungals and are only active against two types of fungus ….and ….

Answer 12

candida and aspergillous

Question 13

what monitoring is ESSENTIAL for frlucytosine

Answer 13

FBC for bone marrow supression

Question 14

which antifungal should you not get pregnant with for 1 month after
or father a baby for 6 weeks after

Answer 14

grisiofulvin

Question 15

what 2 toxicities might occur with terbinifine

Answer 15

liver tox

skin reactions - including SJS

Question 16

which antifungal requires an IV test dose due to anaphlyaxis risk

Answer 16

amphotericin

Question 17

what should you do if someone develops a rash with fluconazole

Answer 17

stop (risk of SJS) also rashes are more likley in aids

Question 18

what is the MHRA warning for itraconazole

Answer 18

Heart Failure

especially with negz ionotropic drugs such as CCBs

Question 19

if you treat one member of a household for helminths who else should you treat

Answer 19

everyone

Question 20

what is the drug of choice for treating thredworm and hookworm and when do you give

Answer 20

mebendazole once and then again after 6 weeks

combined with hygeine measures

Question 21

what type of delicous wormy worms can cause anemia

Answer 21

hook worms

so treat the worms and the anaemia

Question 22

what wormy worm drug should be gradually increasased to minimise reactions

Answer 22

diethylcarbamazepine