Fungal infections Flashcards
what is the treatment of choice for aspergillosis
voriconazole
what is prescribed systemically for thrush if its resistance to fluconazole (vag or mouth)
itraconazole
who are cryptococcosis and histoplasmosis common in?
what is the treatment of choice?
immunocompromised/HIV
amphotericin
can you itracon for histoplasmosis for non HIV pt
what is the treatment for tinea captidis
griusulfulvin
what do we use for empirical treatment of serious fungal infections in compromised paitents
amphotericin
what type of antifungal is fluconazole
triazole
what type of antifungal is clotrimazole
imidazole
what type of antifuncal is ketoconazole
imidazole
why is fluconazole used more commonly that intraconazole?
what class are they both
less likely to cause hepatotox
triazoles
can nystatin or amphotericin be given by mouth
no - both are poorly absorbed
there are polyene antifungals
amphotericin is highly protein bound and sideeffects are common, what can be done about this
use lipid formulation
anidulafungin, caspofungin and micafungin are echinocandin antifungals and are only active against two types of fungus ….and ….
candida and aspergillous
what monitoring is ESSENTIAL for frlucytosine
FBC for bone marrow supression
which antifungal should you not get pregnant with for 1 month after
or father a baby for 6 weeks after
grisiofulvin
what 2 toxicities might occur with terbinifine
liver tox
skin reactions - including SJS
which antifungal requires an IV test dose due to anaphlyaxis risk
amphotericin
what should you do if someone develops a rash with fluconazole
stop (risk of SJS) also rashes are more likley in aids
what is the MHRA warning for itraconazole
Heart Failure
especially with negz ionotropic drugs such as CCBs
if you treat one member of a household for helminths who else should you treat
everyone
what is the drug of choice for treating thredworm and hookworm and when do you give
mebendazole once and then again after 6 weeks
combined with hygeine measures
what type of delicous wormy worms can cause anemia
hook worms
so treat the worms and the anaemia
what wormy worm drug should be gradually increasased to minimise reactions
diethylcarbamazepine
