Antibiotics things Flashcards
why is parenteral chloramphenicol reserved for life threatening infectiosn
haematological side effects
what antibiotic can cause rhabdomyolysis? therefore shouldnt be used with statins etc and Cr kinase should be monitored
daptomycin
what councelling should be given to pt about telithromycin (2) what class is this
first dose at night- visual disurbances / transient loss of consiousness
hepatic disorders
macrolide
what is metronidazole acitve against (2)
anaerobes and protazoa
how long should you avoid alcohol with a certain antibiotic and which one is this
48 hours after metronidazole
what is the CHM councelling on linezolid (2)
when used for how long
how often to monitor
optic nerve neuropathy - especially if used for over 28 days -report visual disturb -monitor vision regularly blood disorders -especially more than 10-14 days -mylosupression/ renal impair or other affecting drugs -FBC at least weekly
linezolid - what should be closely montiored or avoid taking the linez0olid for patients with phachromatocytoma, thryotoxicosis, bipolar, schiz
blood pressure
also monitor closely if pt has uncontrolled hypertension
What IS linezolid?
How does this change patient councelling?
a reversible MAOI
don’t eat tyramine rick food
dont give with another MAOI/SSRI/5HT ag/TCA etc
possibly also not with opioids
when might cholestatic jaundice occur after treatment with penicillins
2 weeks
what the bloody hell is colistimethate and what are the dose related sideeffects(2)
polymixin - for gram -ve organism like klebsiella
dose dependant nephro and neuro toxicity
what might quinilones impair your ability to do
drive
what are the two indications for rifaximin
travellers diarrhoea not assicated with fever
prevention of encephalopathy
what type of drug is sulfadiazine?
what is its only indication?
what is its main caution?
sulfonamide
prevention of rhuematic fever
stop if blood disorders or tash develop (SJS, thrombocytopaenia etc)
what anti TB drug is likely to cause constipation
isoniazid
