More antibiotics

Question 1

What is the aminoglycaside of choice

Answer 1

gentamycin

Question 2

Is gent active against anearobes?

what is gent usually given with

Answer 2

no

therefore usually given with metronidazole or penicillin when causative organism is unknown

Question 3

aminoglycaside with a cumulative dose where sideeffects increase if exceeded

Answer 3

streptomycin 100g

Question 4

normally aminoglycasides are given using once daily dosing. What conditions are the exceptions (4)

Answer 4

Endocarditis
burns of over 20% of body area
CrCl

Question 5

2 common side effects of aminogylcasides

Answer 5

oto and nephrotox

Question 6

when should gent levels be taken for multiple daily dose regieme?

what are the levels
and the levels in endocarditis

Answer 6

1 hour peak 5-10mg/L (3-5mg/mL in endocarditis)

pre dose trough

Question 7

What colour does nitrofuranitoin turn the urine

Answer 7

orange brown

Question 8

Mode of action of gent

Answer 8

Aminoglycasides - affect the 30 S subuint

Question 9

Mode of action of glycopepties

Answer 9

inihbit cell wall synthesis

Question 10

Vancomycin is what class of antibiotic

Answer 10

glycopeptic

Question 11

Side effects of vacomycin (2)

Monitoring (3)

Answer 11

oto and nephrotox

FBC, CrCl, urinalysis

Question 12

What should vanc levels be

Answer 12

10-15mg/ml pre third dose

Question 13

How often is vanc dosing

Answer 13

every 12 hours

Question 14

tertracyclines - should avoid indegestions remadies within ……

Answer 14

2 hours

Question 15

mode of action of tetracyclines

Answer 15

targeting 30s subunit

Question 16

what class of antibiotics can cause oesophogeal irritation

Answer 16

tetracyclines

Question 17

macrolides are broad or narrow spec

Answer 17

broad

Question 18

e.g. of macrolides

Answer 18

clarythromycin and erthromycin

Question 19

what is the effect of macrolides on liver enxymes

Answer 19

inhibition

Question 20

side effects of clarithryomycin (mouth sideeffects)

Answer 20

teeth and toungue discolouration

Question 21

mode of action of macrolides

Answer 21

protein synthesis 50 S subunit

Question 22

effect of rifampicin on digoxin and theophylin

Answer 22

reduces plasma concentration

Question 23

effect of refampicin on hepatic enzymes

Answer 23

inducer

Question 24

mode of action of refiampicin

Answer 24

inihibts nucleaic acid synthesis

Question 25

side effects of refampicin

Answer 25

colitis annorexia urine discolouration liver tox

Question 26

what colour does rifampcin colour urine

Answer 26

red

Question 27

cephlaspiron warning

Answer 27

antibiotic associated colitis

Question 28

quinilone warnings in other chronic conditions

Answer 28

lowers the seizure threshold in epilepsy

Question 29

mode of aciton of quinilones

Answer 29

nucleic acid synthesis - DNA gyrase

Question 30

ciprofloxacin and anything -oxacin is an example of

Answer 30

quinilones

Question 31

s/e of quinilones that is caution in children

Answer 31

joint disorders

Question 32

effect of quinilones on liver enzymes

Answer 32

inhibitor

Question 33

s/e of quinilones (3)

Answer 33

headache, sleep disturbance dizziness

Question 34

is fluclxacillin inactivated by peniciliinases?

Answer 34

no

Question 35

cautions of fluclose

Answer 35

cholestatic jaundice

Question 36

what organism is tasozin used for

Answer 36

pseudomonas

Question 37

Trimethorpime coucelling

Answer 37

blood dyscrasias (sore throat)

Question 38

more of action of trimethoprim

Answer 38

inhibits folate synthesis

Question 39

s/e of trimethoprim (3(

Answer 39

hyperkalaemia rashes blood discrasias

Question 40

can you use trimethoprim in pregnancy

Answer 40

NO