Virbio Species Flashcards
In term so environment, sypmtoms of infectino and mortality rate, compare and contrast each of the three species of pathogenic Vibrio
Parahaemolyticus - cool water but >15C - diarrhea, nausea, vomitng, fever - very low mortality rate Vulnificus - warm water - fever, chills, nausea, skin lesions - 40-60% Cholerae - Tropical water - rice water stool, loss of appetitie -1% mortality rate, worse case
What are the virulence factors for each of the Vibrio species?
Parahaemolyticus - tdh and trh Vulnificus - capsule, LPS vvha Cholerae -cholerae toxin (CTX)
The syndromes: Primary Septicemia and necrotizing wound infections is found in what vibrio species?
Vibrio vulnificus, more fatal, 60% fatality
Which vibrio species have picked up virulence factors that cause illness?
V. cholerae, V. parahaemolyticus, V. vulnificus
Situation: A grup of people had eaten raw oysters and are experiencing symptoms of fever, cramps, diarrhea, headaches, nausea and vomiting, what pathogen is this?
Vibrio haemolyticus
Why is it more likely to get Vibrio pathogens in the summer?
Colder waters produce safety seafood, above 17C when harvested can lead to infections
What are some important virulence factors )for living) for Vibrio parahaemolyticus?
Vibrioferrin, Ferrichrome, Aerobactin all lyze blood for Fe acquisition (hameolysis) → transported into cell by ABC transporters
Flagella for movement
MAM7 for initial adhesion to epithelial cells
Is TDH or TRH toxin form Vibrio more pathogenic?
TDH is more pathogenic than TRH (hamoelyticus)
Thermostable direct heamolysin (tdh)
Thermoliable haemolysin (tlh
thermostable direct-related haemolysin (trh)
What is oaraheamolyticus serotypes?
LPS (o) antigen and capsular polysaccharide (K) antigen
Situation: someone with liver dieases by alcoholism and Hep C infection came in wtih these symptoms:
“Hurting legs, sudden onset of intense burning sensation from both feet to upper thighs
No traume, bt minor scratches on knees
Eaten raw oysters 2 days prior
Fever, vomintg, labored breathing
Rash of legs turned into lesions
This is the most serious vibrio infection by Vibrio Vulnificus
How do you deal with a Virbio culnificus infection?
Surgery to clean infected tissue, amputation
IS vulnificus serotyped?
No, it has three biotypes 1- humans, 2- eels, 3- Israel
What are the virulence factors of Vibrio vulnificus?
Polysaccharide capsule (K-antigens) LPS (O=antigen) → fever and systemic infection/shock vvhA (heat stable haemolysin/cytotoxin)
What are instances that increase your likelihood of getting Vibrio vulnificus infection?
Comorbidities such as chronic ones, liver, alcoholism, diabetes, renal
Where is Vibrio Cholerae common?
Areas with unstable politics, earthquakes and poor sanitization
