Campylobacter

Question 1

When are there peaks in Camp?

Answer 1

Summer due to chickens, temperature

Question 2

What are some symptoms of Camp?

Answer 2

Gastroenteritis
Brain Absecesses
Periodontis
Guillian Barre.Miller Fischer 
Inflammatory Bowel Disease
Esophageal
Bacteremia

Question 3

What are the pathogeniticyt factors>

Answer 3

Motility
Adhesion of CadF
Protein secretion and invasion
Actin polymerization
Toxin production

CadF is a fibronectin binding proteins
PEB1 is a periplasmic binding protein
J1pA is a surface exposed lipoprotein
CiaB is an exported virulence factor

Question 4

What toxin does Campylobacter produce?

Answer 4

Cytolethal distending toxin (Cdt) - ABC
binds to cell membrane, allows for entry, reaches nulceus and destorys the cell
- increased permeablity of the epithelium and results in diarrhea

Question 5

Explain Guillian Barre Syndrome

Answer 5

Symptoms begin with motor and sensory deifictis in lower extremities
Thought to develop antibodies against certain antigens in the bacteria LPS that cross react with peripheral nerve cell gangliosides
Attacke myelin sheath and expose nerve fibers

Question 6

How to reduce CAmpylobacter?

Answer 6

Educating farmers
No thinning of broiler 
Biosecurity
Age of broilers at processing
Fly netting