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Food Borne Pathogens > E. coli > Flashcards

E. coli Flashcards

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1
Q

What are the 8 strains of Ecoli?

A 
AIEC
ETEC
EAEC
STEC
EIEC
DAEC
EPEC
UPEC
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2
Q

AIEC?

A

IBD

related to UPEC but has adhesion

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3
Q

UPEC?

A

urinary pathogenic, no adehsion, invasion or intracellular replication

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4
Q

ETEC?

A

Enterotoxigenic

Heat labile and Heat stable enterotoxins

diarrhea

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5
Q

EAEC?

A

Enteroaggregate

1) adhere to intestinal mucosa
2) Enterotoxin cytotoxins
3) mucosa inflammed (toxins and immune) –> diarrhea

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6
Q

STEC?

A

Shiga toxin
no antibiotic
can have LEE positive genes

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7
Q

DAEC?

A

afa/Dr binds to epi and destorys microvilli

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8
Q

EPEC

A

locus of netrocyLEE genes

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9
Q

EIEC?

A

enteroinvasiceshigella

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10
Q

Which EC attack enterocytesthrough rearrangment of actin iflaments?

A

EPEC and STEC

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11
Q

Which EC invade goblet cells which leads to inflammation?

A

EAEC

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12
Q

Which EC is an intracellular pathogens that penetrate the intestinal epithelium through M cells to gain the submucosa. EIEC escape submucosal macrophages by induction of macrophage cell death followed by basolateral invasion of colonocytes and later spread

A

EIEC/Sigella

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13
Q

Which EC uses colonization factors (CF) for attachment to host intestinal cells

A

ETEC

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14
Q

Which EC disperes over the surface of cells of the intestinal cells, resulting diffuse adherence

A

DAEC

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15
Q

Which EC colonizes the intestinal mucosa of patients with Chron’s disease and is capable of invading epithelial cells as well as replicating within macrophages

A

AIEC

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16
Q

Which EC do not have viruelnce factors?

A

AIEC, ETEC

17
Q

Which EC results in HUS? What is HUS?

A

EIEC/Shigella
HUS is Hemolytic uremic syndrome- rHUS caused by the destruction of red blood cells. The damaged RBC clog the filtering system in the kidneys which can lead to life threatening kidney failure

18
Q

Which EC has LEE genes?

A

EPEC
UEPEC
STEC

19
Q

Which EC requires antibitoics? Which don’t?

A

YES-
EIEC/shigella

NO-
Shiga/STEC as that causes stress and could lead to HUS
ETEC AMR

20
Q

Which EC carry Stx?

A

EIEC

STEC

21
Q

How is Shiga toxin (Stx acquired?)

A

bacteriophage

22
Q

What are the viruelnce factors of Eneteroaggregative EV (EAEC)?

A

Variability in virulence factors and toxins
Cells adhere to intestinal mucosa
Produce enterotoxins and cytotosins
Mucosa becomes inflamed due to toxins and immune system (diarrhea)

23
Q

What EC can result in HUS?

A

EIEC and STEC

Food Borne Pathogens (16 decks)

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