E. coli Flashcards
What are the 8 strains of Ecoli?
AIEC ETEC EAEC STEC EIEC DAEC EPEC UPEC
AIEC?
IBD
related to UPEC but has adhesion
UPEC?
urinary pathogenic, no adehsion, invasion or intracellular replication
ETEC?
Enterotoxigenic
Heat labile and Heat stable enterotoxins
diarrhea
EAEC?
Enteroaggregate
1) adhere to intestinal mucosa
2) Enterotoxin cytotoxins
3) mucosa inflammed (toxins and immune) –> diarrhea
STEC?
Shiga toxin
no antibiotic
can have LEE positive genes
DAEC?
afa/Dr binds to epi and destorys microvilli
EPEC
locus of netrocyLEE genes
EIEC?
enteroinvasiceshigella
Which EC attack enterocytesthrough rearrangment of actin iflaments?
EPEC and STEC
Which EC invade goblet cells which leads to inflammation?
EAEC
Which EC is an intracellular pathogens that penetrate the intestinal epithelium through M cells to gain the submucosa. EIEC escape submucosal macrophages by induction of macrophage cell death followed by basolateral invasion of colonocytes and later spread
EIEC/Sigella
Which EC uses colonization factors (CF) for attachment to host intestinal cells
ETEC
Which EC disperes over the surface of cells of the intestinal cells, resulting diffuse adherence
DAEC
Which EC colonizes the intestinal mucosa of patients with Chron’s disease and is capable of invading epithelial cells as well as replicating within macrophages
AIEC
Which EC do not have viruelnce factors?
AIEC, ETEC
Which EC results in HUS? What is HUS?
EIEC/Shigella
HUS is Hemolytic uremic syndrome- rHUS caused by the destruction of red blood cells. The damaged RBC clog the filtering system in the kidneys which can lead to life threatening kidney failure
Which EC has LEE genes?
EPEC
UEPEC
STEC
Which EC requires antibitoics? Which don’t?
YES-
EIEC/shigella
NO-
Shiga/STEC as that causes stress and could lead to HUS
ETEC AMR
Which EC carry Stx?
EIEC
STEC
How is Shiga toxin (Stx acquired?)
bacteriophage
What are the viruelnce factors of Eneteroaggregative EV (EAEC)?
Variability in virulence factors and toxins
Cells adhere to intestinal mucosa
Produce enterotoxins and cytotosins
Mucosa becomes inflamed due to toxins and immune system (diarrhea)
What EC can result in HUS?
EIEC and STEC
