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IMSE (FINALS) > viral serology (EBV) > Flashcards

viral serology (EBV) Flashcards

1
Q

diagnosis

  • Indirect Hemagglutination ≥ (1:256)
  • EIA (+)
A

E. histolytica

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2
Q

diagnosis

  • ASO (≥ 1:240)
  • Anti-DNAse B (≥ 1:240)
  • Anti-Hyaluronidase (≥ 1:512)
A

S. pyogenes

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3
Q

diagnosis

  • Immunodiffusion (+)
  • Latex Particle Agglutination (≥ 1:80)
A

Candida sp.

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4
Q

diagnosis

  • Cold Agglutinins ≥ 1:128
  • Complement Fixation ≥ 1:32
  • EIA (+)
A

M. pneumoniae

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5
Q

can distinguish heterophile sheep cell agglutinins in human serum caused by IM, serum sickness, and Forssman antigen.

A

davidsohn differential test

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6
Q
  • principle: absorption-hemeagglutination
  • exposure of test serum to both beef and guinea pig cells which causes absorption of either one or both of these antibodies
  • guinea pig cells and beef rbcs
  • heterophil Abs in patient’s serum
  • indicator cells: sheep rbcs
  • the “absorbed agglutinins” (precipitates) are removed by centrifugation and the resultant fluid (supernatant) are then tested with sheep rbc
A

davidsohn differential test

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7
Q

are stimulated by one antigen and will react with unrelated antigens from different mammalian species.

A

heterophile antibodies

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8
Q

diagnosis

  • Immunodiffusion (+)
  • Complement Fixation (≥ 1:32)
A
  • Aspergillus sp.
  • H. capsulatum
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9
Q

reacts with sheep, ox (beef), horse and guinea pig cells

A

heterophil antibodies in serum sickness

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10
Q

most useful marker for acute IM

A

IgM anti-VCA

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11
Q

diagnosis

  • Indirect IFA ≥ 1:64
  • EIA (+)
  • Western Blot IgG ≥ 4 of 9 bands
  • Western Blot IgM ≥ 2 of 9 bands
A

B. burgdorferi

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12
Q

diagnosis

  • Indirect IFA (≥ 1:64)
  • EIA (+)
A
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13
Q
  • EA-D is also found in the (?).
  • IgG antibodies to EA-D can be indicators of (?).
  • IgG antibodies to EA-R are sometimes seen in young children who have active (?), but not in infected young adults.
A
  • nucleus
  • active disease
  • IM infection
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14
Q

present at the onset of IM, persist for life (which indicates past infection)

A

IgG anti-VCA

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15
Q

Causative agent of: Burkitt’s Lymphoma, Nasopharyngealcarcinoma, Infectious Mononucleosis (IM)

A

EBV

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16
Q

diagnosis

  • Indirect Hemagglutination ≥ (1:128)
  • EIA (+)
A

Cystercosis

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17
Q

diagnosis

EIA (+)

A

H. pylori

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18
Q
  • is an acute, self-limiting disease typically seen in young adults.
  • The disease is characterized by fever, sore throat, cervical lymphadenopathy, splenomegaly, and mild hepatitis.
  • The WBC count is elevated, and reactive lymphocytes are seen in the peripheral blood.
  • There is a relative and absolute lymphocytosis.
  • The average incubation period is approximately 2 to 8 weeks
A

infectious mononucleosis (IM)

19
Q

used for any substance that stimulated the formation of sheep hemolysin (anti-sheep cells)

A

forssman antigen

20
Q

diagnosis

  • RPR (+)
  • VDRL (+)
  • FTA-ABS (+)
A

T. pallidum

21
Q

diagnosis

  • Immunodiffusion (+)
  • EIA (≥ 1:32)
A

B. dermatitidis

22
Q
  • reacts with sheep cells, ox (beef) cells and horse cells but not with guinea pig cells
  • not forssman in nature
A

heterophil antibodies in IM

23
Q

diagnosis

Indirect IFA (≥ 1:64)

A
  • R. rickettsi
  • E. chaffeensis
24
Q

diagnosis

Indirect IFA (≥ 1:128)

A

B. henselae

25
Q

(?) antibodies to EBNA develop slowly but can remain detectable throughout life.

A

IgG

26
Q
  • The heterophile antibodies of IM are (?) antibodies and are seen in 50% to 70% of patients with IM.
  • They persist for (?) to (?) weeks after infection.
A
  • IgM
  • 4, 8
27
Q
  • guinea pig cells are injected into rabbits» Ab fotmation
  • Abs formed: anti-guinea pig cells and anti-sheep cells
A

forssman

28
Q
  • principle: absorption-hemeagglutination
  • guniea pig, kidney cells, and beef rbcs
  • heterophil Abs in patient’s serum
  • indicator cells: horse rbcs
  • same patterns with davidson
A

monospot

29
Q

diagnosis

Indirect IFA (≥ 1:256)

A

L. pneumophila

30
Q

based on the principle that horse RBCs are agglutinated by the heterophile antibodies of IM.

A

monospot test

31
Q
  • principle: hemeagglutination
  • presumptive/screening test
  • incapable of determining specificity and is only indicative of the presence or absence of heterophil Abs
  • 2% suspension of sheep rbcs
  • heterophil Abs in patient’s serum
  • (+) result: hemaggln = presence of heterophil Abs
A

paul bunnel test

32
Q
  • The virus is ubiquitous; 80% to 90% of healthy (?) have EBV antibodies.
  • EBV infects (?)
A
  • adults
  • B lymphocytes
33
Q
  • (?) antibodies against VCA are detectable early in the infections, but disappear within (?) to (?) months.
  • (?) antibodies against VCA develop within (?) week after infection and can persist for life.
A
  • IgM
  • 2, 4
  • IgG
  • 1
34
Q

diagnosis

  • Bentonite Flocculation (≥ 1:5)
  • EIA (+)
A

T. spira

35
Q

reacts with guinea pig cells, horse and sheep cells but not with beef cells

A

heterophil antibodies of forssman

36
Q

antibodies produced by unrelated species which can cross-react with the same antigen

A

heterophil antibodies

37
Q

appears during convalescence

A

anti-EBA

38
Q

diagnosis

EIA (≥ 1:32)

A

Toxocara sp.

39
Q

found in the nuclei of all infected cells.

A

EBNA (epstein-barr nuclear antigen)

40
Q

diagnosis

Widal Test (≥ 1:160)

A

S. typhi

41
Q
  • Can detect only the presence or absence of heterophile antibodies.
  • It cannot determine the specificity of the antibodies
A

paul-bunnell test

42
Q

seen also in acute IMS

A

anti-EAD

43
Q

are found in the cytoplasm of infected B lymphocytes.

A
  • EA-D (early antigen-diffuse)
  • EA-R (early antigen-restricted)
44
Q

found in the cytoplasm of EBV infected lymphocytes.

A

VCA (viral capsid antigen)

IMSE (FINALS) (8 decks)

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