Viral response Flashcards
which paper
Huber 2014
adaptive arm of the immune response is important in
limiting and clearing viral infection
humorula response
antibodies specific to virus
antibodies
capture and neutralise virus before it enters another host cell
if antibodies are ineffective
viruses are able to infect host cells- can only be cleared by cellular arm of the immune system
virus uses protein synthesis machinery of
host cell
once virus has started using host machinery to synthesise own proteins…
some of the newly mae proteins will be degraded into peptide fragments and bind to MHC I molecules
MHC I peptide complex presented to
CD8 T cell
what providee stimulation necessary for CD8 T cell
DC and CD4 T cell
during initial phase of viral infection
signify increase in number of CD8 T cell
antigen presenting cells that reside at the site of infection can…
take up viral particles from extracellular sources- present them on MHC II molecules
CD4 T cells can subsequently
be activated by recognising particle in MHC II molecles
CD4 T cells provide
cytokine sand chemokine that exert cytotoxic function
Th1 generally characterised by production of
IFN-Y and TNF-a
Th generally characterised by
production of IL-4, Il-5 and IL-13
