Immunostimulation with Toll-like receptor agonists in cancer therapy

Question 1

reference for this paper

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Iribarren, 2015

Question 2

accumulating evidence that

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TLR againsts can aid in immune targeting of tumour cells

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TLR agonists have been successfully employed to ameliorate

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efficacy of various chemotherapeutics and anticancer agents

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Immunostimulation involves

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artificially activating TLRs on macrophages and dendritic cells

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TLRs constitute a

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first line defence

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TLRs promote which immune effector functions

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phagocytosis, antigen presentation and cytokine secretion (turn on the adaptive immune system- CD8)

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TLRs and cancer

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TLRs respond to DAMPs

Question 8

name an example of a TLR agonist

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• MPLA (adjuvant)

- Pam3CSK4

Question 9

example of a TLR agonist drug for cancer and which TLR it targets

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IMO-2055- TLR 9 agonist

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IMO-2055

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TLR 9 agonist

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IMO-2055 is given in combination with other anti-cancer drugs

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erlotinib and bevacizumab

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which cancer does IMO-2055 target

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non-small-cell lung carcinoma

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how many people enrolled in smith study

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36

Question 14

how many patient disease stablised

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60%- tolerated well

Question 15

over ….. clinical trials testing TLR agonists

Answer 15

48