Bacterial immunity extra reading

Question 1

myeloid phagocytes

Answer 1

macrophages, DCs and neutrohils

Question 2

roles of myeloid phagocytes

Answer 2

inflammation, immunity and tissue repair, initiation of adaptive immune system

Question 3

for phagocytes to clear pathogenic microorganism

Answer 3

phagocyte must first detect the microorganism using PRR, then engulf and kill

Question 4

only a few receptors have been found to be sufficient to mediate phagocytosis when pressed alone

Answer 4

Fc receptors- antibody-opsonised particles

dectin 1 for fungal B-1,3-glucans

Question 5

dectin 1

Answer 5

fungal B-1,3-glucans

Question 6

phagocytosis has a central role in

Answer 6

finding out information about the article, deciding what type of threat is posed- eliciting an approve response

Question 7

Underhill paper talks about

Answer 7

PHAGOCYTOSIS

Question 8

Phagocytosis reference

Answer 8

Underhill -2012

Question 9

intracellular bacteria reference

Answer 9

ismail 2002

Question 10

Ismail 2002 says…

Answer 10

innate response to intracellular bacteria- phagocytosis and destruction (fuse with lysosome)

Adaptive- CTL

Question 11

ismail 2002 says that

Answer 11

studies in human and animal models will enhance understanding of intracellular bacterial infection

Question 12

innate immune recognition of bacteria is the

Answer 12

first requirement for mounting an effective immune response to infection

Question 13

Ferrand 2013 says that

Answer 13

cytoplasmic sensors (NLR) play a key role of sensing not only intracellular pathogens, but also extracellular bacterial pathogens