Pam3 CSK4

Question 1

which paper

Answer 1

sousa 2011

Question 2

chromoblastomycosis is a

Answer 2

chronic skin infection

Question 3

what causes chromoblastomycosis

Answer 3

Fonscaea pedrosoi

Question 4

what did sousa 2011 find

Answer 4

chronic nature of chromoblastomycosis is sure to lack of pattern recognition receptor costimualtion

Question 5

F.pedrosoi is recognised by

Answer 5

Mincle (C-type lectin receptor)

Question 6

F.pedrosoi is not recognised by

Answer 6

Toll-like receptors (TLRs)

Question 7

lack of stimulation by TLR

Answer 7

defective induction of pro inflammatory response

Question 8

inflammatory response to F.pedrosoi could be

Answer 8

reinstated by TLR costimualtion

Question 9

signaling via which pathway of mincle

Answer 9

Syk/CARD9 pathway

Question 10

signaling via which pathway of TLR2

Answer 10

MyD88

Question 11

recognition of fungal B-glucans by macrophages is not sufficient

Answer 11

to induce inflammatory response

Question 12

whilst addition of F.pedrosoi conidia to macrophages..

Answer 12

failed to induce significant levels o TNF

Question 13

costimulation with

Answer 13

Pam3CSK4 induces a robust response

Question 14

Pam3CSK4 is a

Answer 14

TLR2 agonist- induce MyD88