T-cell response

Question 1

reference for main paper

Answer 1

Kaiko, 2008

Question 2

aberrant T cell response

Answer 2

underlines many diseases e.g. asthma and autoimmune disease

Question 3

immune elements of diseases such as asthma and autoimmune diseases..

Answer 3

T helper cells

• Th1 and Th2
• Th17

Question 4

in order to identify crucial processes in the pathogenesis of diseases

Answer 4

critical to understand how development of T cell occurs

Question 5

the elucidation of the mechanisms of selection of T cell phenotype wull

Answer 5

facilitate the development of therapeutic strategies

Question 6

development of polarised Th cells from naive T cell is complex involving stimulation from

Answer 6

TLRs

activation and maturation of DCs, which leads to TCR engagement and cytokine release

Question 7

phenotype f T cell is

Answer 7

influenced by the tissue microenvironment

Question 8

Th1 development is promoted by

Answer 8

IL-12
IL-18
T1 IFN
IFN-Y

Question 9

Th1 involve what signalling

Answer 9

STAT1, -2,-3 and T0bet signaling

Question 10

Th1 development probably promoted by

Answer 10

IL-4
IL-6
IL-11
ICOS costimualting

Question 11

Th2 involve what signalling

Answer 11

STAT6, GATA-3 and c-MAf

Question 12

what needs further research

Answer 12

a better understanding of these phenotypes

Question 13

in diseases such as

Answer 13

multiple sclerosis, asthma and IBD aberrant CD4 T cell response plays a crucial role in pathogenesis

Question 14

understanding the mechanisms of polarisation of aberrant T cells

Answer 14

is pivotal for the development of effective prevention and treatment

Question 15

who’s paper is this again

Answer 15

Kaiko 2008