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Y2C1 Ufuk > Viral pathogenesis > Flashcards

Viral pathogenesis Flashcards

1
Q

respiratory tract:mucociliary blanket

_____cells
_____cells
Sub-epithelial_____secreating glands

A

ciliated cells
goblet cells
mucous secreting

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2
Q

alimentary tract

M cells activated via ?

A

leucoytes

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3
Q

Urogenital Tract

Mucus and low pH of vagina
___virus-genital warts
___virus-infection of immune system
___virus-infection of sensory and autonomic neurons

A

HPV
HIV
HSV

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4
Q

systemic spread of virus from____is rare

A

eyes

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5
Q

Infection primarily occurs when Integrity of____is corrupted

breached by breaks,punctures, bites of animals etc

A

skin

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6
Q

B-viral spread

hematogeneous spread
____&_____capillaries are spread ways
direct inoculation by_____bite

A

blood & lymphatic
vector bite

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7
Q

B-viral spread

2 types exist
___spread
____spread

A

hematogenous
neural

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8
Q

viral spread types:neural spread

many viruses spread from primary site of infection by entering local_____endings

a-HSVs and rabies is one of examples of viruses spread this way

A

local nerve

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9
Q

neural spread

viruses can enter from
_____nerve ending
_____end plate

A

sensory
motor

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10
Q

organ invasion

skin,kidney,pancreas,colon through____&____
liver & spleen through____

A

capillaries & venules
sinusoids

invaded capillaries & venules lined by endothelial cells

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11
Q

Invasion of fetus

____&____tissue
Infected circulating cells may enter fetal bloodstream directly
Virus may also be transmitted to baby during____or_____feeding

A

placental & fetal
delivery or breast feeding

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12
Q

host control of viral spread:early non-immune control

type__interferons(IF__and__)
* inducers ds RNA transcription of new genes used as an immune inducer to treat____viral inf.
*____cells Complement system,____cleavage

A

type 1 IF-a & b
transcription used as to treat persistent viral inf.
natural killer cells
proteolytic cleavage

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13
Q

host control of viral spread:immune control

what are immune control ways ?

A

humoral & cellular

both adaptive

humoral=neutralization, antibody dependent lysis of infected cells
cellular=Inflammatory response

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14
Q

virus-host interactions

3 types exist which are ?

A

permissive infection(lytic infection)
abortive(restrictive)
persistent

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15
Q

virus-host cell interactions:persistent infection

____infection:restricted gene expression
_____infection:production of progeny may be slower
_____infection:prolonged incubation period

A

latent
chronic
slow

HSV causes latent infection

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16
Q

latent infections:general properties

viral gene products that promote productive repliaction are not made or found in____concentrations

A

low

17
Q

state of viral genome in latency

_____DNA is a non-dividing cell
____&____in neurons

A

non-replicating
HSV,VZV

18
Q

state of viral genome in latency

5 viruses causes autonomous self-replicating DNA in dividing cell what are their names ?

A

EBV,CMV,HPV,HBV,KSHV

19
Q

state of viral genome in latency

___virus integrated into host chromosome, replicates with host

A

HHV6

20
Q

Transforming Infections

DNA or RNA___viruses may convert a normal cell into a malignant one

A

tumor viruses

21
Q

Transforming Infections:naming viruses

HPV
HBV
HHV-8
EBV
HTLV-1
HCV
write the names of given viruses below

A

Human Papilloma Virus
Hepatitis B virus
Kaposi Sarcoma virus
Epstein-Barr virus
Human T Lymphotropic virus
Hepatitis C virus

22
Q

Viral determinants of pathogenesis:tissue tropism

viral affinity for spesific tissues_____determined by cell receptors for virus
HIV—>
COVİD-19—>

A

tropism
CD4
ACE2

23
Q

viral virulence

is capacity of a virus to___

A

cause disease

24
Q

viral virulence genes

affect____replication
encoding modifiers of______mechanisms
enable virus to spread in host
encoding___

A

viral
host defense
toxins

25
Q

____of rptavirus is an enterotoxin

info can be found at viral virulence genes
in viral pathology

if you feel blue check it out

A

NSP4 gp

26
Q

cellular virtulence determinants

mutations in____,_____,_____or_____predispose human carriers to HSV encephalitis

mutations cause host more infectious to HSV

A

TLR3
UNC-93B
TRIF
TRAF3

27
Q

cellular virtulence determinants

______mutations protects from HIV infection

viral infection–>host factors modifying viral pathogenesis

check if feels blue

A

CCR5-delta32

28
Q

direct cell damage_____Induced
Indirect____ınduced

viral pathogenesis–>cellular pathogenesis of viral Infections

A

virus
host

29
Q
A

Y2C1 Ufuk (5 decks)

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