Viral pathogenesis Flashcards
respiratory tract:mucociliary blanket
_____cells
_____cells
Sub-epithelial_____secreating glands
ciliated cells
goblet cells
mucous secreting
alimentary tract
M cells activated via ?
leucoytes
Urogenital Tract
Mucus and low pH of vagina
___virus-genital warts
___virus-infection of immune system
___virus-infection of sensory and autonomic neurons
HPV
HIV
HSV
systemic spread of virus from____is rare
eyes
Infection primarily occurs when Integrity of____is corrupted
breached by breaks,punctures, bites of animals etc
skin
B-viral spread
hematogeneous spread
____&_____capillaries are spread ways
direct inoculation by_____bite
blood & lymphatic
vector bite
B-viral spread
2 types exist
___spread
____spread
hematogenous
neural
viral spread types:neural spread
many viruses spread from primary site of infection by entering local_____endings
a-HSVs and rabies is one of examples of viruses spread this way
local nerve
neural spread
viruses can enter from
_____nerve ending
_____end plate
sensory
motor
organ invasion
skin,kidney,pancreas,colon through____&____
liver & spleen through____
capillaries & venules
sinusoids
invaded capillaries & venules lined by endothelial cells
Invasion of fetus
____&____tissue
Infected circulating cells may enter fetal bloodstream directly
Virus may also be transmitted to baby during____or_____feeding
placental & fetal
delivery or breast feeding
host control of viral spread:early non-immune control
type__interferons(IF__and__)
* inducers ds RNA transcription of new genes used as an immune inducer to treat____viral inf.
*____cells Complement system,____cleavage
type 1 IF-a & b
transcription used as to treat persistent viral inf.
natural killer cells
proteolytic cleavage
host control of viral spread:immune control
what are immune control ways ?
humoral & cellular
both adaptive
humoral=neutralization, antibody dependent lysis of infected cells
cellular=Inflammatory response
virus-host interactions
3 types exist which are ?
permissive infection(lytic infection)
abortive(restrictive)
persistent
virus-host cell interactions:persistent infection
____infection:restricted gene expression
_____infection:production of progeny may be slower
_____infection:prolonged incubation period
latent
chronic
slow
HSV causes latent infection
latent infections:general properties
viral gene products that promote productive repliaction are not made or found in____concentrations
low
state of viral genome in latency
_____DNA is a non-dividing cell
____&____in neurons
non-replicating
HSV,VZV
state of viral genome in latency
5 viruses causes autonomous self-replicating DNA in dividing cell what are their names ?
EBV,CMV,HPV,HBV,KSHV
state of viral genome in latency
___virus integrated into host chromosome, replicates with host
HHV6
Transforming Infections
DNA or RNA___viruses may convert a normal cell into a malignant one
tumor viruses
Transforming Infections:naming viruses
HPV
HBV
HHV-8
EBV
HTLV-1
HCV
write the names of given viruses below
Human Papilloma Virus
Hepatitis B virus
Kaposi Sarcoma virus
Epstein-Barr virus
Human T Lymphotropic virus
Hepatitis C virus
Viral determinants of pathogenesis:tissue tropism
viral affinity for spesific tissues_____determined by cell receptors for virus
HIV—>
COVİD-19—>
tropism
CD4
ACE2
viral virulence
is capacity of a virus to___
cause disease
viral virulence genes
affect____replication
encoding modifiers of______mechanisms
enable virus to spread in host
encoding___
viral
host defense
toxins
