Tissue Renewal and Repair Flashcards

1
Q

The restoration of tissue architecture and function after an injury is referred to as __________.

A

Repair

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2
Q

The two main types of reactions involved in tissue repair are __________ and __________.

A

Regeneration, Connective tissue deposition (scar formation)

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3
Q

Scar formation occurs when tissues are incapable of __________ or if the supporting structures are severely damaged.

A

Complete restitution

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4
Q

The ability of tissues to repair themselves is determined by their intrinsic __________ capacity.

A

Proliferative

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5
Q

Tissues that continuously divide and regenerate after injury are classified as __________ tissues.

A

Labile

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6
Q

The process of new blood vessel development from existing vessels during tissue repair is called __________.

A

Angiogenesis

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7
Q

Growth factors such as __________ and __________ play a significant role in stimulating angiogenesis.

A

VEGFs, FGFs

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8
Q

In scar formation, fibroblasts deposit __________ to provide structural stability.

A

Collagen

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9
Q

The transition from granulation tissue to a mature scar involves the remodeling of __________.

A

Connective tissue

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10
Q

The healing process that involves epithelial regeneration with minimal scarring is known as __________.

A

Healing by first intention (primary union)

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11
Q

In the second week of wound healing, there is continued accumulation of __________ and proliferation of __________.

A

Collagen, Fibroblasts

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12
Q

Labile tissues include __________ cells in the bone marrow and __________ epithelia in the skin.

A

Hematopoietic, Surface

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13
Q

Stable tissues, such as the __________, can proliferate in response to injury but are normally in a quiescent state.

A

Liver

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14
Q

The majority of neurons and cardiac muscle cells are classified as __________ tissues.

A

Permanent

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15
Q

Chronic wounds, such as venous leg ulcers and pressure sores, are examples of defects in __________.

A

Healing

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16
Q

Hypertrophic scars are characterized by the presence of abundant __________ and tend to __________ over time.

A

Myofibroblasts, Regress

17
Q

The cytokine __________ is critical for the synthesis and deposition of connective tissue proteins during scar formation.

A

TGF-β