Herpesvirus Flashcards
The genome of herpesviruses is composed of ______ DNA.
dsDNA
The herpesvirus genome is approximately ______ to ______ base pairs long.
124,000 to 235,000
Herpesviruses penetrate host cells by ______ and uncoating.
direct fusion
The uncoating of herpesviruses leads to the release of the ______ into the cytoplasm.
nucleocapsid
Herpes simplex virus-1 (HSV-1) primarily establishes latency in the ______ and ______ ganglia.
sensory, cranial
Varicella-Zoster virus (VZV) can reactivate later in life, causing ______.
shingles
Shingles primarily affects the ______ dermatomes.
sensory
Cytomegalovirus (CMV) establishes latency in ______ cells.
myeloid
Cytomegalovirus replicates in ______ cells and ______ cells.
blood leukocytes, endothelial
Kaposi’s Sarcoma-Related Virus (KSRV) is also known as ______.
HHV-8
HHV-8 is associated with the development of ______ in immunocompromised patients.
Kaposi’s sarcoma
Epstein-Barr virus (EBV) establishes latency primarily in ______ cells.
memory B
Epstein-Barr virus (EBV) can lead to diseases such as ______ and ______.
Burkitt’s lymphoma, nasopharyngeal carcinoma
The primary means of transmission for HSV-1 and HSV-2 is through ______, ______, and ______.
direct contact, sexual intercourse, perinatal transmission
Herpes simplex virus targets ______ cells for lytic infection.
mucoepithelial
