Viral hepatitis Flashcards
What type of genetic material do hepatitis viruses A, C, D and E all posses?
RNA
What type of genetic material does the hep B virus posses?
dsDNA
Which group of patients is susceptible to the hep D virus?
Hep B patients
What is the route of transmission for Hep A?
Faecal-oral
What are the routes of transmission for Hep B?
Sexual Vertical Horizontal Blood products
What is the route of transmission for Hep C?
Blood products
What is the route of transmission for Hep E?
Faecal-oral
Which 2 types of antibody does the body produce in response to hep A? And in what timeframe?
IgM - develop soon after exposure and fade away after a couple of months. IgG antibodies develop later and remain present in the body. Also produced in response to vaccination
Hep B has both an acute and chronic phase. How long after exposure does the acute infection present?
less than 6 months
What risk does hep B pose to immunocompromised patients?
Latent virus can reactivate
What percentage of acute Hep C infections progress to chronic?
80%
How is acute Hep A diagnosed and for how long is this possible?
Anti-HAV IgM (IgM persists up to 14 weeks)
How is HBV diagnosed?
ALT ↑ AST ↑ HBsAg HBeAg HBcAb (Acute IgM, chronic IgG)
How is HCV diagnosed?
ALT ↑ Anti-HCV antibodies
How is HAV managed?
Supportive management
