Viral Etiology Of Tumors Flashcards
Mention 7 things that may cause cancer.
Viruses Environment Diet Genetics Age Immune system
How may viruses cause cancer?
Some viral genetic information carried in the Nucleic Acids of the virus may enter the chromosome of the infected cell and cause malignancy
The ____ century saw the first descriptions of cancer-causing viruses
20th century
________ & ________ are retroviruses in the category that were discovered
Avian Sacroma virus/Rous
Avian Leukaemia virus/Ellerman & Bang
Who discovered that retroviruses cause tumors in mice?
Ludwig Goss in 1950
_______________ discovered Feline Leukemia virus
William Jarrett
Human T lymphotropic virus is associated with ________ cancer
Adult T cell leukemia
HTLV is spread transmitted by?
Blood Transfer
Breast milk
What is HTLV1 mechanism of action?
It drives cell growth through the expression of a particular viral protein “Tax” in latently-infected cells
HTLV is a ________ virus
Retrovirus
Epstein-Barr virus is a virus of _______ family.
Herpes family
EBV is also known as _____________
Human Herpesvirus 4
HHV4
Other viruses that being to the Herpes family include?
- Herpes Simplex Virus
2. Cytomegalovirus
EBV-linked malignancies include?
- Burkitt’s lymphoma
2. Nasopharyngeal Carcinoma
A form of skin cancer often associated with AIDS is known as?
Kaposi’s sacroma
Mention the common sites Kaposi’s sacroma can be found.
Upper body: Head, Neck & Back
Uncommonly: Soft palate, gums
Advanced: Lymph nodes, Lungs, Stomach, Intestines
What virus is associated with Cervical Cancer?
Human Papillomavirus
Hepatitis B is a ________ stranded ______ virus in the ___________ family
- Double
- DNA
- Hepadnaviridae
Mention the HBV genomes and what they encode
Pol-DNA polymerase
Env-Envelope Protein
Pre-core-Pre-core protein
X-May be involved in the activation of host cell genes and development of cancer
What cancer could Hepatitis B virus cause?
Hepatocellular Carcinoma, which affects patients with chronic hepatitis
Mention the risk factors for Heptacellular Carcinoma
Hepatitis B & C infection
Alcoholism
Aflatoxins
